Please use this identifier to cite or link to this item: https://doi.org/10.1093/neuonc/not198
Title: Increased sensitivity to radiochemotherapy in IDH1 mutant glioblastoma as demonstrated by serial quantitative MR volumetry
Authors: Tran, A.N. 
Lai, A.
Li, S.
Pope, W.B.
Teixeira, S.
Harris, R.J.
Woodworth, D.C.
Nghiemphu, P.L.
Cloughesy, T.F.
Ellingson, B.M.
Keywords: glioblastoma
IDH1 mutation
MRI
radiochemotherapy
volumetry
Issue Date: Mar-2014
Citation: Tran, A.N., Lai, A., Li, S., Pope, W.B., Teixeira, S., Harris, R.J., Woodworth, D.C., Nghiemphu, P.L., Cloughesy, T.F., Ellingson, B.M. (2014-03). Increased sensitivity to radiochemotherapy in IDH1 mutant glioblastoma as demonstrated by serial quantitative MR volumetry. Neuro-Oncology 16 (3) : 414-420. ScholarBank@NUS Repository. https://doi.org/10.1093/neuonc/not198
Abstract: BackgroundIsocitrate dehydrogenase 1 (IDH1) mutations have been linked to favorable outcomes in patients with glioblastoma multiforme (GBM). Recent in vitro experiments suggest that IDH1 mutation sensitizes tumors to radiation damage. We hypothesized that radiographic treatment response would be significantly different between IDH1 mutant versus wild-type GBMs after radiotherapy (RT) and concurrent temozolomide (TMZ).MethodsA total of 39 newly diagnosed GBM patients with known IDH1 mutational status (10 IDH1 mutants), who followed standard therapy and had regular post-contrast T1W (T1+C) and T2W/fluid-attenuated inversion recovery (FLAIR) images in the 6-month period after starting RT, were enrolled. The volume of contrast-enhancing and FLAIR hyperintensity were calculated from each scan. Linear and polynomial regression techniques were used to estimate the rate of change and temporal patterns in tumor volumes.ResultsIDH1 mutant GBMs demonstrated a favorable response to RT/TMZ in the study period, as demonstrated by 10 of 10 mutants showing radiographic response (decreasing VT1+C), compared with 13 of 29 wild-types (P 105 days for VFLAIR and 95-120 and >150 days for V T1+C from starting RT/TMZ.ConclusionsThe current study supports the hypothesis that IDH1 mutant GBMs are more sensitive to radiochemotherapy than IDH1 wild-type GBMs. © 2013 The Author(s).
Source Title: Neuro-Oncology
URI: http://scholarbank.nus.edu.sg/handle/10635/125008
ISSN: 15228517
DOI: 10.1093/neuonc/not198
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

65
checked on Oct 4, 2022

WEB OF SCIENCETM
Citations

63
checked on Oct 4, 2022

Page view(s)

124
checked on Oct 6, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.