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Title: Detection of mycobacterial antibodies in serum samples by enzyme linked immunosorbent assay
Authors: Nath, S.S.
Nathiya, K.
Dhanabalan, R.
Angayarkanni, J. 
Palaniswamy, M.
Keywords: Enzyme-linked immunosorbent assay (ELISA)
Mycobacterial antigens
Issue Date: Nov-2011
Citation: Nath, S.S., Nathiya, K., Dhanabalan, R., Angayarkanni, J., Palaniswamy, M. (2011-11). Detection of mycobacterial antibodies in serum samples by enzyme linked immunosorbent assay. African Journal of Biotechnology 10 (71) : 16012-16015. ScholarBank@NUS Repository.
Abstract: Tuberculosis (TB) is a common and deadly infectious disease caused by Mycobacterium tuberculosis and rarely by other subspecies of the M. tuberculosis complex, such as Mycobacterium bovis. Enzymelinked immunosorbent assay (ELISA) for diagnosis of tuberculosis has been widely explored over the years. The purpose of this study was to reduce the time duration required for the diagnosis of tuberculosis. We have extracted antigens from the M. tuberculosis strain H37Ra. Antibody response was studied using ELISA. A total of 30 samples were analysed for their specificity and sensitivity. Of which, 20 were positive and the sensitivity and specificity of the test appeared to be 89%. The high sensitivities, specificities and promising antigenic combination in detection of TB suggest their potential application in diagnosis of TB. © 2011 Academic Journals.
Source Title: African Journal of Biotechnology
ISSN: 16845315
DOI: 10.5897/AJB11.1302
Appears in Collections:Staff Publications

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