Please use this identifier to cite or link to this item: https://doi.org/10.1111/ajco.12038
Title: Combined temozolomide and radiation as an initial treatment for anaplastic glioma
Authors: Tham, C.K.
See, S.J. 
Tan, S.H. 
Lim, K.H.C. 
Ng, W.H. 
Thomas, J. 
Chong, D.Q.
Chua, E.T. 
Keywords: Anaplastic glioma
Radiation
Temozolomide
Issue Date: Sep-2013
Citation: Tham, C.K., See, S.J., Tan, S.H., Lim, K.H.C., Ng, W.H., Thomas, J., Chong, D.Q., Chua, E.T. (2013-09). Combined temozolomide and radiation as an initial treatment for anaplastic glioma. Asia-Pacific Journal of Clinical Oncology 9 (3) : 220-225. ScholarBank@NUS Repository. https://doi.org/10.1111/ajco.12038
Abstract: Aim: Combined temozolomide (TMZ) and radiation therapy (RT) is often used as initial treatment for anaplastic glioma. However, there is no prospective randomized data available that proves the efficacy of the combination for anaplastic glioma. In this retrospective study we aimed to compare the outcome of patients who had combined TMZ and RT with those who had RT alone for the initial treatment of anaplastic glioma in our centers. Methods: Patients with anaplastic astrocytoma or oligoastrocytoma treated at our centers between 2000 and 2010 were reviewed. Only patients who received initial RT or concurrent TMZ and RT (TMZ-RT) were included. Results: Of 62 patients, 55 were less than 66-years old; 36 (58.1%) had a tumor resection and 26 had a biopsy only. An oligodendroglial component in their tumor histology was present in 21 patients (33.9%). At a median follow up of 20.7 months for all patients, median progression-free survival was similar for the two treatment groups (RT alone: 16.7 months (95% CI 9.4, 34.8 months) versus TMZ-RT: 14.8 months (95% CI 8.6, 28.6 months, P=NS). Median overall survival was 27.4 months (95% CI 10.6, not estimable [NE] months) for patients who had RT alone and 34.1 months (95% CI 19.8, 42.1 months) for those who had TMZ-RT. Conclusion: No significant benefit of combined TMZ with RT compared to RT alone was observed as the initial treatment of anaplastic glioma. Prospective randomized trials are needed to evaluate the optimal treatment for this disease. © 2012 Wiley Publishing Asia Pty Ltd.
Source Title: Asia-Pacific Journal of Clinical Oncology
URI: http://scholarbank.nus.edu.sg/handle/10635/124891
ISSN: 17437555
DOI: 10.1111/ajco.12038
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

8
checked on Sep 16, 2019

WEB OF SCIENCETM
Citations

7
checked on Sep 16, 2019

Page view(s)

26
checked on Sep 6, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.