Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biopsych.2014.01.020
Title: Network dysfunction in Alzheimer's disease and frontotemporal dementia: Implications for psychiatry
Authors: Zhou, J. 
Seeley, W.W.
Keywords: Alzheimer's disease
biomarker
connectome
frontotemporal dementia
network
psychiatric disorders
Issue Date: 1-Apr-2014
Citation: Zhou, J., Seeley, W.W. (2014-04-01). Network dysfunction in Alzheimer's disease and frontotemporal dementia: Implications for psychiatry. Biological Psychiatry 75 (7) : 565-573. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biopsych.2014.01.020
Abstract: Structural and functional connectivity methods are changing how researchers conceptualize and explore neuropsychiatric disease. Here, we summarize emerging evidence of large-scale network dysfunction in Alzheimer's disease and behavioral variant frontotemporal dementia, focusing on the divergent impact these disorders have on the default mode network and the salience network. We update a working model for understanding the functions of these networks within a broader anatomical context and highlight the relevance of this model for understanding psychiatric illness. Finally, we look ahead to persistent challenges in the application of network-based imaging methods to patients with Alzheimer's disease, behavioral variant frontotemporal dementia, and other neuropsychiatric conditions. Recent advances and persistent needs are discussed, with an eye toward anticipating the hurdles that must be overcome for a network-based framework to clarify the biology of psychiatric illness and aid in the drug discovery process. © 2014 Society of Biological Psychiatry.
Source Title: Biological Psychiatry
URI: http://scholarbank.nus.edu.sg/handle/10635/124879
ISSN: 18732402
DOI: 10.1016/j.biopsych.2014.01.020
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