Please use this identifier to cite or link to this item: https://doi.org/10.4161/gmic.28681
Title: Metabolic tinkering by the gut microbiome: Implications for brain development and function
Authors: Selkrig, J.
Wong, P. 
Zhang, X. 
Pettersson, S.
Keywords: Glucose
Gut microbiota
Hypothalamic-pituitary-adrenal axis
Metabolism
Microbiota-gut-brain axis
Neurodevelopment
Short chain fatty acids
β-hydroxybutyrate
Issue Date: 31-Mar-2014
Citation: Selkrig, J., Wong, P., Zhang, X., Pettersson, S. (2014-03-31). Metabolic tinkering by the gut microbiome: Implications for brain development and function. Gut Microbes 5 (3) : -. ScholarBank@NUS Repository. https://doi.org/10.4161/gmic.28681
Abstract: Brain development is an energy demanding process that relies heavily upon diet derived nutrients. Gut microbiota enhance the host's ability to extract otherwise inaccessible energy from the diet via fermentation of complex oligosaccharides in the colon. This nutrient yield is estimated to contribute up to 10% of the host's daily caloric requirement in humans and fluctuates in response to environmental variations. Research over the past decade has demonstrated a surprising role for the gut microbiome in normal brain development and function. In this review we postulate that perturbations in the gut microbial-derived nutrient supply, driven by environmental variation, profoundly impacts upon normal brain development and function. © 2014 Landes Bioscience.
Source Title: Gut Microbes
URI: http://scholarbank.nus.edu.sg/handle/10635/124870
ISSN: 19490984
DOI: 10.4161/gmic.28681
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