Please use this identifier to cite or link to this item: https://doi.org/10.1002/adhm.201300053
Title: Functional morphometric analysis in cellular behaviors: Shape and size matter
Authors: Yu, H.
Lim, K.P.
Xiong, S.
Tan, L.P.
Shim, W. 
Keywords: Cell behaviors
Cell shape
Morphology characterization
Shape analysis
Issue Date: Sep-2013
Citation: Yu, H., Lim, K.P., Xiong, S., Tan, L.P., Shim, W. (2013-09). Functional morphometric analysis in cellular behaviors: Shape and size matter. Advanced Healthcare Materials 2 (9) : 1188-1197. ScholarBank@NUS Repository. https://doi.org/10.1002/adhm.201300053
Abstract: Cellular morphogenesis in response to biophysical and topographical cues provides insights into cytoskeletal status, biointerface communications, and phenotypic adaptations in an incessant signaling feedback that governs cellular fate. Morphometric characterization is an important element in the study of the dynamic cellular behaviors, in their interactive response to environmental influence exerted by culture system. They collectively serve to reflect cellular proliferation, migration, and differentiation, which may serve as prognostic indices for clinical and pathological diagnosis. Various parameters are proposed to categorize morphological adaptations in relation to cellular function. In this review, the underlying principles, assumptions, and limitations of morphological characterizations are discussed. The significance, challenges, and implications of quantitative morphometric characterization of cell shapes and sizes in determining cellular functions are discussed. This is the first comprehensive review on common methodologies in morphological characterization of cellular systems. In this review, the underlying principles, assumptions, and limitations of morphological characterizations are discussed. The significance, challenges, and implications of quantitative morphometric characterization of cell shapes and sizes in cellular function are highlighted. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Advanced Healthcare Materials
URI: http://scholarbank.nus.edu.sg/handle/10635/124866
ISSN: 21922640
DOI: 10.1002/adhm.201300053
Appears in Collections:Staff Publications

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