Please use this identifier to cite or link to this item: https://doi.org/10.1172/JCI57144
Title: Ceramides as modulators of cellular and whole-body metabolism
Authors: Bikman, B.T. 
Summers, S.A. 
Issue Date: 1-Nov-2011
Citation: Bikman, B.T., Summers, S.A. (2011-11-01). Ceramides as modulators of cellular and whole-body metabolism. Journal of Clinical Investigation 121 (11) : 4222-4230. ScholarBank@NUS Repository. https://doi.org/10.1172/JCI57144
Abstract: Nearly all stress stimuli (e.g., inflammatory cytokines, glucocorticoids, chemotherapeutics, etc.) induce sphingolipid synthesis, leading to the accumulation of ceramides and ceramide metabolites. While the role of these lipids in the regulation of cell growth and death has been studied extensively, recent studies suggest that a primary consequence of ceramide accumulation is an alteration in metabolism. In both cell-autonomous systems and complex organisms, ceramides modify intracellular signaling pathways to slow anabolism, ensuring that catabolism ensues. These ceramide actions have important implications for diseases associated with obesity, such as diabetes and cardiovascular disease.
Source Title: Journal of Clinical Investigation
URI: http://scholarbank.nus.edu.sg/handle/10635/124854
ISSN: 00219738
DOI: 10.1172/JCI57144
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

256
checked on Jul 31, 2021

WEB OF SCIENCETM
Citations

250
checked on Jul 23, 2021

Page view(s)

65
checked on Jul 31, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.