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Title: Cognitive deficits in mild Parkinson's disease are associated with distinct areas of grey matter atrophy
Authors: Mak, E.
Zhou, J. 
Tan, L.C.S.
Au, W.L. 
Sitoh, Y.Y.
Kandiah, N. 
Issue Date: 2014
Citation: Mak, E., Zhou, J., Tan, L.C.S., Au, W.L., Sitoh, Y.Y., Kandiah, N. (2014). Cognitive deficits in mild Parkinson's disease are associated with distinct areas of grey matter atrophy. Journal of Neurology, Neurosurgery and Psychiatry 85 (5) : 576-580. ScholarBank@NUS Repository.
Abstract: Background and objectives The neuroanatomical substrates underlying cognitive impairment in Parkinson's disease (PD) remain poorly understood. To address this gap, we compared the grey matter atrophy patterns in PD patients with mild cognitive impairment (PD-MCI) with PD patients having no cognitive impairment (PDNCI), and examined relationships between atrophic regions and cognitive performance in specific domains. Methods 90 non-demented PD patients (64.95 ±7.54 years, Hoehn and Yahr=1.88±0.39) were classified using formal diagnostic criteria as PD-MCI (n=23) or PD-NCI (n=67). Grey matter volume differences were examined using voxel-based morphometry on structural MRI, and multivariate linear regressions were employed to assess the relationships between cognitive performance in specific domains and atrophic regions. Results Patients with PD-MCI had lower global cognition scores compared with PD-NCI (Mini Mental State Examination: 26.9 vs28.4, p=0.011; Montreal Cognitive Assessment: 24.5 vs 27.0, p
Source Title: Journal of Neurology, Neurosurgery and Psychiatry
ISSN: 1468330X
DOI: 10.1136/jnnp-2013-305805
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