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Title: Adipose-derived stem cells: Fatty potentials for therapy
Authors: Ong, W.K.
Sugii, S. 
Keywords: Adipose-derived stromal cells
Fat development and origin
iPS cells/iPSCs
Preadipocyte/adipocytic progenitor
Regenerative therapies
Issue Date: Jun-2013
Citation: Ong, W.K., Sugii, S. (2013-06). Adipose-derived stem cells: Fatty potentials for therapy. International Journal of Biochemistry and Cell Biology 45 (6) : 1083-1086. ScholarBank@NUS Repository.
Abstract: Adipose-derived stem cells (ASCs) are the mesenchymal stem cell (MSC) population found in the stromal-vascular fraction (SVF) of fat tissue. White adipose tissue (WAT), with well-established roles in lipid storage and adipokine secretion, is advantageous over bone marrow as the source of MSCs due to relative abundance and ease of isolation of the tissue. ASCs reside perivascularly within WAT and physiologically undergo adipogenesis to support WAT expansion in response to increased energy intake. Apart from adipogenesis, ASCs can be induced in vitro to differentiate into osteoblasts, chondroblasts, myocytes, neurons and other cell types. ASCs can also be reprogrammed to induced pluripotent stem (iPS) cells more efficiently than other cell types. ASCs are immunoprivileged cells and secrete immunomodulatory, angiogenic, anti-apoptotic and haematopoietic factors that facilitate tissue repair. The multi-lineage differentiation capacity, unique immunobiological properties and secretome of ASCs offer tremendous therapeutic potentials in regenerative medicine. © 2013 Elsevier Ltd.
Source Title: International Journal of Biochemistry and Cell Biology
ISSN: 13572725
DOI: 10.1016/j.biocel.2013.02.013
Appears in Collections:Staff Publications

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