Please use this identifier to cite or link to this item: https://doi.org/10.1128/JVI.03076-13
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dc.titleMorbillivirus control of the interferon response: Relevance of STAT2 and mda5 but not STAT1 for canine distemper virus virulence in ferrets
dc.contributor.authorSvitek, N.
dc.contributor.authorGerhauser, I.
dc.contributor.authorGoncalves, C.
dc.contributor.authorGrabski, E.
dc.contributor.authorDöring, M.
dc.contributor.authorKalinke, U.
dc.contributor.authorAnderson, D.E.
dc.contributor.authorCattaneo, R.
dc.contributor.authorVon Messling, V.
dc.date.accessioned2016-06-01T10:28:54Z
dc.date.available2016-06-01T10:28:54Z
dc.date.issued2014-03
dc.identifier.citationSvitek, N., Gerhauser, I., Goncalves, C., Grabski, E., Döring, M., Kalinke, U., Anderson, D.E., Cattaneo, R., Von Messling, V. (2014-03). Morbillivirus control of the interferon response: Relevance of STAT2 and mda5 but not STAT1 for canine distemper virus virulence in ferrets. Journal of Virology 88 (5) : 2941-2950. ScholarBank@NUS Repository. https://doi.org/10.1128/JVI.03076-13
dc.identifier.issn0022538X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/124771
dc.description.abstractThe V proteins of paramyxoviruses control the innate immune response. In particular, the V protein of the genus Morbillivirus interferes with the signal transducer and activator of transcription 1 (STAT1), STAT2, and melanoma differentiation-associated protein 5 (mda5) signaling pathways. To characterize the contributions of these pathways to canine distemper virus (CDV) pathogenesis, we took advantage of the knowledge about the mechanisms of interaction between the measles virus V protein with these key regulators of innate immunity. We generated recombinant CDVs with V proteins unable to properly interact with STAT1, STAT2, or mda5. A virus with combined STAT2 and mda5 deficiencies was also generated, and available wild-type and V-protein-knockout viruses were used as controls. Ferrets infected with wild-type and STAT1-blind viruses developed severe leukopenia and loss of lymphocyte proliferation activity and succumbed to the disease within 14 days. In contrast, animals infected with viruses with STAT2 or mda5 defect or both STAT2 and mda5 defects developed a mild self-limiting disease similar to that associated with the V-knockout virus. This study demonstrates the importance of interference with STAT2 and mda5 signaling for CDV immune evasion and provides a starting point for the development of morbillivirus vectors with reduced immunosuppressive properties. © 2014, American Society for Microbiology.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1128/JVI.03076-13
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1128/JVI.03076-13
dc.description.sourcetitleJournal of Virology
dc.description.volume88
dc.description.issue5
dc.description.page2941-2950
dc.description.codenJOVIA
dc.identifier.isiut000331131700050
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