Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0031561
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dc.titleElements in the canine distemper virus M 3′ UTR contribute to control of replication efficiency and virulence
dc.contributor.authorAnderson, D.E.
dc.contributor.authorCastan, A.
dc.contributor.authorBisaillon, M.
dc.contributor.authorVon Messling, V.
dc.date.accessioned2016-06-01T10:28:37Z
dc.date.available2016-06-01T10:28:37Z
dc.date.issued2012-02-13
dc.identifier.citationAnderson, D.E., Castan, A., Bisaillon, M., Von Messling, V. (2012-02-13). Elements in the canine distemper virus M 3′ UTR contribute to control of replication efficiency and virulence. PLoS ONE 7 (2) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0031561
dc.identifier.issn19326203
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/124763
dc.description.abstractCanine distemper virus (CDV) is a negative-sense, single-stranded RNA virus within the genus Morbillivirus and the family Paramyxoviridae. The Morbillivirus genome is composed of six transcriptional units that are separated by untranslated regions (UTRs), which are relatively uniform in length, with the exception of the UTR between the matrix (M) and fusion (F) genes. This UTR is at least three times longer and in the case of CDV also highly variable. Exchange of the M-F region between different CDV strains did not affect virulence or disease phenotype, demonstrating that this region is functionally interchangeable. Viruses carrying the deletions in the M 3′ UTR replicated more efficiently, which correlated with a reduction of virulence, suggesting that overall length as well as specific sequence motifs distributed throughout the region contribute to virulence. © 2012 Anderson et al.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1371/journal.pone.0031561
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1371/journal.pone.0031561
dc.description.sourcetitlePLoS ONE
dc.description.volume7
dc.description.issue2
dc.description.page-
dc.identifier.isiut000302733900054
dc.published.statePublished
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