Please use this identifier to cite or link to this item: https://doi.org/10.1002/dvdy.22712
Title: Mutated in colorectal cancer (Mcc), a candidate tumor suppressor, is dynamically expressed during mouse embryogenesis
Authors: Young, T.
Poobalan, Y.
Ali, Y.
Siew Tein, W. 
Sadasivam, A.
Ee Kim, T.
Erica Tay, P.
Dunn, N.R.
Keywords: Ectoderm
Embryo
Endoderm
Expression
Genetrap
Mcc
Mesoderm
Mouse
Issue Date: Sep-2011
Citation: Young, T., Poobalan, Y., Ali, Y., Siew Tein, W., Sadasivam, A., Ee Kim, T., Erica Tay, P., Dunn, N.R. (2011-09). Mutated in colorectal cancer (Mcc), a candidate tumor suppressor, is dynamically expressed during mouse embryogenesis. Developmental Dynamics 240 (9) : 2166-2174. ScholarBank@NUS Repository. https://doi.org/10.1002/dvdy.22712
Abstract: Mutated in Colorectal Cancer (MCC) encodes a multiple PSD-95/Dlg/ZO-1 (PDZ) domain-containing protein implicated, as its name suggests, in the pathogenesis of human colon cancer. To date, however, what role, if any, MCC plays in normal tissue homeostasis and development remains unclear. In an effort to expand our understanding of MCC function and distribution, we examined the expression of the evolutionarily conserved mouse Mcc homolog between embryonic days (E) 6.5 and 12.5 using conventional whole-mount in situ hybridization and two independent Mcc reporter alleles. Mcc is expressed in the posterior primitive streak during gastrulation and in diverse tissues of both mesodermal and endodermal origin. In addition, Mcc transcripts localize to the posterior neural tube and identify discrete neuronal subtypes and ganglia within the developing central nervous system. Genetically, however, Mcc is entirely dispensable, as mice homozygous for the Mcc Gt(D062B07) gene trap allele, which generates a loss-of-function mutation, are viable and fertile, with no ostensible phenotype. © 2011 Wiley-Liss, Inc.
Source Title: Developmental Dynamics
URI: http://scholarbank.nus.edu.sg/handle/10635/124730
ISSN: 10588388
DOI: 10.1002/dvdy.22712
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