Please use this identifier to cite or link to this item:
|Title:||Why are East Asians more susceptible to several infection-associated cancers (carcinomas of the nasopharynx, stomach, liver, adenocarcinoma of the lung, nasal NK/T-cell lymphomas)?||Authors:||Wee, J.
|Issue Date:||Dec-2012||Citation:||Wee, J., Nei, W.L., Yeoh, K.W., Yeo, R.M., Loong, S.L., Qian, C.-N. (2012-12). Why are East Asians more susceptible to several infection-associated cancers (carcinomas of the nasopharynx, stomach, liver, adenocarcinoma of the lung, nasal NK/T-cell lymphomas)?. Medical Hypotheses 79 (6) : 833-842. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mehy.2012.09.003||Abstract:||There are at least five cancers with uniquely high incidence amongst East and Southeast Asian ethnic groups - namely nasopharyngeal carcinoma (NPC); gastric carcinoma; hepatocellular carcinoma (HCC); adeno-carcinoma of the lung in female non-smokers and nasal NK/T-cell lymphomas. They all appear to be related to an infective cause (Epstein Barr Virus, Helicobacter pylori, hepatitis B virus). We hypothesize that a genetic bottleneck 30,000. years ago at the Last Glacial Maximum could have resulted in unique genetic polymorphisms in Toll-like receptor 8, making East Asians more vulnerable to these infective associated cancers. This bottleneck could have been caused by the presence of malaria in the southern Himalayan conduit between central and East Asia; and only those with an attenuated innate immune response to the malarial parasite (perhaps reflected by the TLR8 polymorphism) were spared the ravages of cerebral malaria; allowing these people to cross into east Asia, but then rendering them susceptible to later endemic infections and their associated cancers. © 2012 Elsevier Ltd.||Source Title:||Medical Hypotheses||URI:||http://scholarbank.nus.edu.sg/handle/10635/124728||ISSN:||03069877||DOI:||10.1016/j.mehy.2012.09.003|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 1, 2020
WEB OF SCIENCETM
checked on Dec 1, 2020
checked on Nov 28, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.