Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.virol.2011.10.018
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dc.titleVirulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferrets
dc.contributor.authorMeunier, I.
dc.contributor.authorEmbury-Hyatt, C.
dc.contributor.authorStebner, S.
dc.contributor.authorGray, M.
dc.contributor.authorBastien, N.
dc.contributor.authorLi, Y.
dc.contributor.authorPlummer, F.
dc.contributor.authorKobinger, G.P.
dc.contributor.authorVon Messling, V.
dc.date.accessioned2016-06-01T10:26:53Z
dc.date.available2016-06-01T10:26:53Z
dc.date.issued2012-01-05
dc.identifier.citationMeunier, I., Embury-Hyatt, C., Stebner, S., Gray, M., Bastien, N., Li, Y., Plummer, F., Kobinger, G.P., Von Messling, V. (2012-01-05). Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferrets. Virology 422 (1) : 125-131. ScholarBank@NUS Repository. https://doi.org/10.1016/j.virol.2011.10.018
dc.identifier.issn00426822
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/124712
dc.description.abstractSeveral early pandemic H1N1 influenza isolates cause severe disease in different animals models, while most strains result in mild clinical signs similar to seasonal influenza. In this study, the pathogenesis of the virulent Mexican isolate A/Mexico/InDRE4487/2009 and a mild Canadian isolate A/Canada-AB/RV1532/2009 was compared in ferrets. These viruses differed at nine residues, none of which has been previously identified as virulence factor. The Mexican isolate caused more severe disease and higher mortality, and reached higher peak nasal wash titers. Both viruses grew similarly in the respiratory tract, but only the virulent virus was detected in the gut after day 3. During the acute phase, both strains caused similar lung pathology, however the Mexican isolate induced severe inflammation even after virus clearance. This virus was also associated with a rapid and sustained induction of inflammatory cytokines, indicating that early dysregulation of the host response contributes importantly to the disease outcome. © 2011 Elsevier Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.virol.2011.10.018
dc.sourceScopus
dc.subjectFerret model
dc.subjectH1N1 2009 pandemic influenza
dc.subjectHistopathological differences
dc.subjectInflammatory host response profile
dc.subjectMild and severe strains
dc.subjectPathogenesis comparison
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1016/j.virol.2011.10.018
dc.description.sourcetitleVirology
dc.description.volume422
dc.description.issue1
dc.description.page125-131
dc.description.codenVIRLA
dc.identifier.isiut000297902300014
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