Please use this identifier to cite or link to this item: https://doi.org/10.1253/circj.CJ-12-1155
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dc.titleRole of tumor necrosis factor-α in the pathogenesis of atrial fibrosis and development of an arrhythmogenic substrate
dc.contributor.authorLiew, R.
dc.contributor.authorKhairunnisa, K.
dc.contributor.authorGu, Y.
dc.contributor.authorTee, N.
dc.contributor.authorYin, N.O.
dc.contributor.authorNaylynn, T.M.
dc.contributor.authorMoe, K.T.
dc.date.accessioned2016-06-01T10:26:45Z
dc.date.available2016-06-01T10:26:45Z
dc.date.issued2013
dc.identifier.citationLiew, R., Khairunnisa, K., Gu, Y., Tee, N., Yin, N.O., Naylynn, T.M., Moe, K.T. (2013). Role of tumor necrosis factor-α in the pathogenesis of atrial fibrosis and development of an arrhythmogenic substrate. Circulation Journal 77 (5) : 1171-1179. ScholarBank@NUS Repository. https://doi.org/10.1253/circj.CJ-12-1155
dc.identifier.issn13469843
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/124708
dc.description.abstractBackground: Although tumor necrosis factor-α (TNF-α) levels are increased in patients with atrial fibrillation (AF), its role in the pathogenesis of AF is unclear. We investigated whether direct delivery of TNF-α could induce atrial fibrosis. Methods and Results: TNF-α (4 μg/kg) was injected into the tail vein of 20 male Swiss albino mice (TNF group) and saline into 20 control mice (CON group). The dose was carefully chosen to avoid any significant decrease in left ventricular (LV) function. Animals were killed after 16 weeks and their atria examined for fibrosis. We found increased atrial fibrosis in the TNF group compared with the CON group [372.8±21.5 arbitrary units (a.u.) vs. 56.9±6.5 a.u., respectively, mean ± SEM; P
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1253/circj.CJ-12-1155
dc.sourceScopus
dc.subjectAtrial fibrosis
dc.subjectImmunohistochemistry
dc.subjectTransforming growth factor-β
dc.subjectTumor necrosis factor-α
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1253/circj.CJ-12-1155
dc.description.sourcetitleCirculation Journal
dc.description.volume77
dc.description.issue5
dc.description.page1171-1179
dc.description.codenCJIOB
dc.identifier.isiut000318320000015
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