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Title: Cortical reorganization of motor functional areas in cerebral arteriovenous malformations
Authors: Lee, L.
Sitoh, Y.Y.
Ng, I.
Ng, W.H. 
Keywords: Cerebral arteriovenous malformation
Cortical reorganization
Eloquent area
Functional MRI
Issue Date: May-2013
Citation: Lee, L., Sitoh, Y.Y., Ng, I., Ng, W.H. (2013-05). Cortical reorganization of motor functional areas in cerebral arteriovenous malformations. Journal of Clinical Neuroscience 20 (5) : 649-653. ScholarBank@NUS Repository.
Abstract: Cerebral arteriovenous malformations (AVM) are congenital malformations that may grow in functional areas such as the primary motor cortex, but do not lead to motor deficits unless they rupture. We attempted to determine whether cortical reorganization was present in patients with AVM. We identified 22 patients with AVM who undergone had motor functional MRI (fMRI) evaluation. Patients were categorized according to AVM location: Group 1-away from motor areas (13 patients, 59.1%); Group 2-adjacent to motor areas (3 patients, 13.6%); and Group 3-overlying motor areas (6 patients, 27.3%). Groups 2 and 3 were compared to Group 1. In Group 3, six of six patients demonstrated cortical reorganisation (p = 0.00037), and the four who underwent AVM removal did not sustain new neurological deficits. In Groups 1 and 2 no patient showed cortical reorganisation. Evidence of cortical reorganisation in patients with AVM overlying eloquent areas suggests that resection of these AVM may be possible with acceptable neurological deficits. © 2012 Elsevier Ltd. All rights reserved.
Source Title: Journal of Clinical Neuroscience
ISSN: 09675868
DOI: 10.1016/j.jocn.2012.07.007
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