Please use this identifier to cite or link to this item: https://doi.org/10.3747/co.21.1660
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dc.titleBilineal T lymphoblastic and myeloid blast transformation in chronic myeloid leukemia with TP53 mutation-an uncommon presentation in adults
dc.contributor.authorKrishnan, S.
dc.contributor.authorSabai, K.
dc.contributor.authorChuah, C.
dc.contributor.authorTan, S.Y.
dc.date.accessioned2016-06-01T10:26:28Z
dc.date.available2016-06-01T10:26:28Z
dc.date.issued2014
dc.identifier.citationKrishnan, S., Sabai, K., Chuah, C., Tan, S.Y. (2014). Bilineal T lymphoblastic and myeloid blast transformation in chronic myeloid leukemia with TP53 mutation-an uncommon presentation in adults. Current Oncology 21 (1) : e147-e150. ScholarBank@NUS Repository. https://doi.org/10.3747/co.21.1660
dc.identifier.issn17187729
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/124699
dc.description.abstractBilineal blast transformation of myeloid and T lymphoid type is a rare event in chronic myeloid leukemia. Here, we report a case in which an adult presented with high white cell counts and lymphadenopathy. Bone marrow studies confirmed the presence of 9 and 22 chromosomal translocation, and a diagnosis of chronic myeloid leukemia in chronic phase was made. Examination of a lymph node showed both myeloid and T lymphoblastoid blast crisis. Molecular studies demonstrated the presence of BCR-ABL fusion transcripts in both the myeloid and the T lymphoblastic component, indicating that the myeloid and T lymphoid blast crisis components shared common progenitors. TP53 deletion was demonstrated by fluorescence in situ hybridization. © 2014 Multimed Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.3747/co.21.1660
dc.sourceScopus
dc.subjectBCR-ABL
dc.subjectBlast transformation
dc.subjectChronic myeloid leukemia
dc.subjectMyeloid sarcoma
dc.subjectT lymphoblastic lymphoma
dc.subjectTP53 mutation
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.3747/co.21.1660
dc.description.sourcetitleCurrent Oncology
dc.description.volume21
dc.description.issue1
dc.description.pagee147-e150
dc.description.codenCUONF
dc.identifier.isiut000331621100017
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