Please use this identifier to cite or link to this item:
https://doi.org/10.3747/co.21.1660
DC Field | Value | |
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dc.title | Bilineal T lymphoblastic and myeloid blast transformation in chronic myeloid leukemia with TP53 mutation-an uncommon presentation in adults | |
dc.contributor.author | Krishnan, S. | |
dc.contributor.author | Sabai, K. | |
dc.contributor.author | Chuah, C. | |
dc.contributor.author | Tan, S.Y. | |
dc.date.accessioned | 2016-06-01T10:26:28Z | |
dc.date.available | 2016-06-01T10:26:28Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Krishnan, S., Sabai, K., Chuah, C., Tan, S.Y. (2014). Bilineal T lymphoblastic and myeloid blast transformation in chronic myeloid leukemia with TP53 mutation-an uncommon presentation in adults. Current Oncology 21 (1) : e147-e150. ScholarBank@NUS Repository. https://doi.org/10.3747/co.21.1660 | |
dc.identifier.issn | 17187729 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/124699 | |
dc.description.abstract | Bilineal blast transformation of myeloid and T lymphoid type is a rare event in chronic myeloid leukemia. Here, we report a case in which an adult presented with high white cell counts and lymphadenopathy. Bone marrow studies confirmed the presence of 9 and 22 chromosomal translocation, and a diagnosis of chronic myeloid leukemia in chronic phase was made. Examination of a lymph node showed both myeloid and T lymphoblastoid blast crisis. Molecular studies demonstrated the presence of BCR-ABL fusion transcripts in both the myeloid and the T lymphoblastic component, indicating that the myeloid and T lymphoid blast crisis components shared common progenitors. TP53 deletion was demonstrated by fluorescence in situ hybridization. © 2014 Multimed Inc. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.3747/co.21.1660 | |
dc.source | Scopus | |
dc.subject | BCR-ABL | |
dc.subject | Blast transformation | |
dc.subject | Chronic myeloid leukemia | |
dc.subject | Myeloid sarcoma | |
dc.subject | T lymphoblastic lymphoma | |
dc.subject | TP53 mutation | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE | |
dc.description.doi | 10.3747/co.21.1660 | |
dc.description.sourcetitle | Current Oncology | |
dc.description.volume | 21 | |
dc.description.issue | 1 | |
dc.description.page | e147-e150 | |
dc.description.coden | CUONF | |
dc.identifier.isiut | 000331621100017 | |
Appears in Collections: | Staff Publications |
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