Please use this identifier to cite or link to this item: https://doi.org/10.3747/co.21.1660
Title: Bilineal T lymphoblastic and myeloid blast transformation in chronic myeloid leukemia with TP53 mutation-an uncommon presentation in adults
Authors: Krishnan, S.
Sabai, K.
Chuah, C. 
Tan, S.Y.
Keywords: BCR-ABL
Blast transformation
Chronic myeloid leukemia
Myeloid sarcoma
T lymphoblastic lymphoma
TP53 mutation
Issue Date: 2014
Citation: Krishnan, S., Sabai, K., Chuah, C., Tan, S.Y. (2014). Bilineal T lymphoblastic and myeloid blast transformation in chronic myeloid leukemia with TP53 mutation-an uncommon presentation in adults. Current Oncology 21 (1) : e147-e150. ScholarBank@NUS Repository. https://doi.org/10.3747/co.21.1660
Abstract: Bilineal blast transformation of myeloid and T lymphoid type is a rare event in chronic myeloid leukemia. Here, we report a case in which an adult presented with high white cell counts and lymphadenopathy. Bone marrow studies confirmed the presence of 9 and 22 chromosomal translocation, and a diagnosis of chronic myeloid leukemia in chronic phase was made. Examination of a lymph node showed both myeloid and T lymphoblastoid blast crisis. Molecular studies demonstrated the presence of BCR-ABL fusion transcripts in both the myeloid and the T lymphoblastic component, indicating that the myeloid and T lymphoid blast crisis components shared common progenitors. TP53 deletion was demonstrated by fluorescence in situ hybridization. © 2014 Multimed Inc.
Source Title: Current Oncology
URI: http://scholarbank.nus.edu.sg/handle/10635/124699
ISSN: 17187729
DOI: 10.3747/co.21.1660
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