Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jns.2013.11.042
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dc.titleCerebral white matter disease is independently associated with BPSD in Alzheimer's disease
dc.contributor.authorKandiah, N.
dc.contributor.authorChander, R.
dc.contributor.authorZhang, A.
dc.contributor.authorYee, C.C.
dc.date.accessioned2016-06-01T10:25:21Z
dc.date.available2016-06-01T10:25:21Z
dc.date.issued2014-02-15
dc.identifier.citationKandiah, N., Chander, R., Zhang, A., Yee, C.C. (2014-02-15). Cerebral white matter disease is independently associated with BPSD in Alzheimer's disease. Journal of the Neurological Sciences 337 (1-2) : 162-166. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jns.2013.11.042
dc.identifier.issn0022510X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/124667
dc.description.abstractObjectives To study the association between cerebral white matter disease and burden of behavioral and psychological symptoms (BPSD) among patients with moderate to severe AD. Methods Patients with moderate to severe AD having undergone MRI brain, cognitive and behavioral evaluations were studied. BPSD was diagnosed based on established clinical guidelines. White matter hyperintensity (WMH) and medial temporal lobe atrophy (MTA) were quantified by a blinded rater. Results 122 AD patients were studied. Age [76.84 vs. 72.70, p = 0.014] and MMSE [11.69 vs. 15.16, p < 0.001] was significantly higher in patients with BPSD. BPSD patients demonstrated higher periventricular [5.44 vs. 4.21, p < 0.001], deep subcortical [5.07 vs. 3.43, p < 0.001], and total WMH [10.51 vs. 7.65, p < 0.001] compared to non-BPSD patients. Higher proportion of BPSD patients had WMH in the highest tertile of severity (82.22% vs. 45.45%, p < 0.001). After correcting for age, baseline cognition and degree of MTA, total WMH remained significantly associated with a diagnosis of BPSD [odds ratio: 1.45 (1.14-1.85; p = 0.002)]. With severe WMH, the association is significantly increased [odds ratio: 4.3 (1.3-12.5); p = 0.016]. Conclusion WMH is independently associated with BPSD in moderate to severe AD. Optimizing vascular risk factors may be a strategy to reduce the severity of BPSD in AD. © 2013 Elsevier B.V.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.jns.2013.11.042
dc.sourceScopus
dc.subjectAlzheimer's disease
dc.subjectBehavioral and psychological symptoms of dementia (BPSD)
dc.subjectCerebral ischemia
dc.subjectMagnetic resonance imaging
dc.subjectNeuropsychology
dc.subjectWhite matter disease
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1016/j.jns.2013.11.042
dc.description.sourcetitleJournal of the Neurological Sciences
dc.description.volume337
dc.description.issue1-2
dc.description.page162-166
dc.description.codenJNSCA
dc.identifier.isiut000332808700028
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