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Title: Multiple indomethacin-induced colonic perforations in an adolescent
Authors: Loh, A.H.P.
Ong, L.Y.
Liew, W.K. 
Arkachaisri, T.
Lee, V.K.M.
Narasimhan, K.L.
Jacobsen, A.S.
Keywords: Adverse drug reactions
Colonic diseases
Intestinal perforation
Non-steroidal anti-inflammatory drugs
Issue Date: Apr-2011
Citation: Loh, A.H.P.,Ong, L.Y.,Liew, W.K.,Arkachaisri, T.,Lee, V.K.M.,Narasimhan, K.L.,Jacobsen, A.S. (2011-04). Multiple indomethacin-induced colonic perforations in an adolescent. Singapore Medical Journal 52 (4) : 82-84. ScholarBank@NUS Repository.
Abstract: Colonic perforation is an uncommon cause of acute abdomen in paediatric patients, and can present a diagnostic enigma as well as management challenge to the paediatric surgeon. An adolescent developed multiple colonic perforations following a short course of oral indomethacin, requiring emergency hemicolectomy. This is the youngest known case of enteral non-steroidal anti-inflammatory drug (NSAID)-mediated large bowel injury. We review current evidence on NSAID-related enteropathy, and postulate potentiating mechanisms that may have accounted for the unusually rapid clinical course of our patient.
Source Title: Singapore Medical Journal
ISSN: 00375675
Appears in Collections:Staff Publications

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