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https://scholarbank.nus.edu.sg/handle/10635/124630
Title: | Multiple indomethacin-induced colonic perforations in an adolescent | Authors: | Loh, A.H.P. Ong, L.Y. Liew, W.K. Arkachaisri, T. Lee, V.K.M. Narasimhan, K.L. Jacobsen, A.S. |
Keywords: | Adverse drug reactions Colonic diseases Indomethacin Intestinal perforation Non-steroidal anti-inflammatory drugs |
Issue Date: | Apr-2011 | Citation: | Loh, A.H.P.,Ong, L.Y.,Liew, W.K.,Arkachaisri, T.,Lee, V.K.M.,Narasimhan, K.L.,Jacobsen, A.S. (2011-04). Multiple indomethacin-induced colonic perforations in an adolescent. Singapore Medical Journal 52 (4) : 82-84. ScholarBank@NUS Repository. | Abstract: | Colonic perforation is an uncommon cause of acute abdomen in paediatric patients, and can present a diagnostic enigma as well as management challenge to the paediatric surgeon. An adolescent developed multiple colonic perforations following a short course of oral indomethacin, requiring emergency hemicolectomy. This is the youngest known case of enteral non-steroidal anti-inflammatory drug (NSAID)-mediated large bowel injury. We review current evidence on NSAID-related enteropathy, and postulate potentiating mechanisms that may have accounted for the unusually rapid clinical course of our patient. | Source Title: | Singapore Medical Journal | URI: | http://scholarbank.nus.edu.sg/handle/10635/124630 | ISSN: | 00375675 |
Appears in Collections: | Staff Publications |
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