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|Title:||Multiple indomethacin-induced colonic perforations in an adolescent||Authors:||Loh, A.H.P.
|Keywords:||Adverse drug reactions
Non-steroidal anti-inflammatory drugs
|Issue Date:||Apr-2011||Citation:||Loh, A.H.P.,Ong, L.Y.,Liew, W.K.,Arkachaisri, T.,Lee, V.K.M.,Narasimhan, K.L.,Jacobsen, A.S. (2011-04). Multiple indomethacin-induced colonic perforations in an adolescent. Singapore Medical Journal 52 (4) : 82-84. ScholarBank@NUS Repository.||Abstract:||Colonic perforation is an uncommon cause of acute abdomen in paediatric patients, and can present a diagnostic enigma as well as management challenge to the paediatric surgeon. An adolescent developed multiple colonic perforations following a short course of oral indomethacin, requiring emergency hemicolectomy. This is the youngest known case of enteral non-steroidal anti-inflammatory drug (NSAID)-mediated large bowel injury. We review current evidence on NSAID-related enteropathy, and postulate potentiating mechanisms that may have accounted for the unusually rapid clinical course of our patient.||Source Title:||Singapore Medical Journal||URI:||http://scholarbank.nus.edu.sg/handle/10635/124630||ISSN:||00375675|
|Appears in Collections:||Staff Publications|
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