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Title: Non-adherence in patients on peritoneal dialysis: A systematic review
Authors: Griva, K. 
Lai, A.Y.
Lim, H.A.
Yu, Z.
Foo, M.W.Y.
Newman, S.P.
Issue Date: 25-Feb-2014
Citation: Griva, K., Lai, A.Y., Lim, H.A., Yu, Z., Foo, M.W.Y., Newman, S.P. (2014-02-25). Non-adherence in patients on peritoneal dialysis: A systematic review. PLoS ONE 9 (2) : -. ScholarBank@NUS Repository.
Abstract: Background: It has been increasingly recognized that non-adherence is an important factor that determines the outcome of peritoneal dialysis (PD) therapy. There is therefore a need to establish the levels of non-adherence to different aspects of the PD regimen (dialysis procedures, medications, and dietary/fluid restrictions). Methods: A systematic review of peer-reviewed literature was performed in PubMed, PsycINFO and CINAHL databases using PRISMA guidelines in May 2013. Publications on non-adherence in PD were selected by two reviewers independently according to predefined inclusion and exclusion criteria. Relevant data on patient characteristics, measures, rates and factors associated with non-adherence were extracted. The quality of studies was also evaluated independently by two reviewers according to a revised version of the Effective Public Health Practice Project assessment tool. Results: The search retrieved 204 studies, of which a total of 25 studies met inclusion criteria. Reported rates of nonadherence varied across studies: 2.6-53% for dialysis exchanges, 3.9-85% for medication, and 14.4-67% for diet/fluid restrictions. Methodological differences in measurement and definition of non-adherence underlie the observed variation. Factors associated with non-adherence that showed a degree of consistency were mostly socio-demographical, such as age, employment status, ethnicity, sex, and time period on PD treatment. Conclusion: Non-adherence to different dimensions of the dialysis regimen appears to be prevalent in PD patients. There is a need for further, high-quality research to explore these factors in more detail, with the aim of informing intervention designs to facilitate adherence in this patient population. © 2014 Griva et al.
Source Title: PLoS ONE
ISSN: 19326203
DOI: 10.1371/journal.pone.0089001
Appears in Collections:Staff Publications

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