Please use this identifier to cite or link to this item: https://doi.org/10.3389/fpsyt.2013.00176
DC FieldValue
dc.titleDysconnectivity in the frontoparietal attention network in schizophrenia
dc.contributor.authorRoiser, J.P.
dc.contributor.authorWigton, R.
dc.contributor.authorKilner, J.M.
dc.contributor.authorMendez, M.A.
dc.contributor.authorHon, N.
dc.contributor.authorFriston, K.J.
dc.contributor.authorJoyce, E.M.
dc.date.accessioned2016-06-01T10:19:35Z
dc.date.available2016-06-01T10:19:35Z
dc.date.issued2013
dc.identifier.citationRoiser, J.P.,Wigton, R.,Kilner, J.M.,Mendez, M.A.,Hon, N.,Friston, K.J.,Joyce, E.M. (2013). Dysconnectivity in the frontoparietal attention network in schizophrenia. Frontiers in Psychiatry 4 (DEC) : -. ScholarBank@NUS Repository. <a href="https://doi.org/10.3389/fpsyt.2013.00176" target="_blank">https://doi.org/10.3389/fpsyt.2013.00176</a>
dc.identifier.issn16640640
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/124514
dc.description.abstractCognitive impairment is common in patients with schizophrenia, and even those with relatively preserved function perform worse than healthy volunteers (HVs) on attentional tasks. This is consistent with the hypothesis that connectivity - in the frontoparietal network (FPN) activated during attention - is disrupted in schizophrenia. We examined attentional effects on connectivity in the FPN, in schizophrenia, using magnetoencephalography (MEG). Twenty-three HVs and 19 first-episode schizophrenia patients were scanned during a simple visual change test, known to activate the FPN, in which attention was monitored and directed with an orthogonal flicker-detection task. Dynamic causal modeling (DCM) of evoked responses was used to assess effective connectivity - and its modulation by changes in the attended stimulus dimension - in the following network: higher visual area; temporoparietal junction (TPJ); intraparietal sulcus (IPS); dorsal anterior cingulate cortex; and ventrolateral prefrontal cortex. The final MEG analysis included 18 HVs and 14 schizophrenia patients. While all participants were able to maintain attention, HVs responded slightly, but non-significantly, more accurately than schizophrenia patients. HVs, but not schizophrenia patients, exhibited greater cortical responses to attended visual changes. Bayesian model comparison revealed that a DCM with attention dependent changes in both top-down and bottom-up connections best explained responses by patients with schizophrenia, while in HVs the best model required only bottom-up changes. Quantitative comparison of connectivity estimates revealed a significant group difference in changes in the right IPS-TPJ connection: schizophrenia patients showed relative reductions in connectivity during attended stimulus changes. Crucially, this reduction predicted lower intelligence. These data are consistent with the hypothesis that functional dysconnections in the FPN contribute to cognitive impairment in schizophrenia. © 2013 Roiser, Wigton, Kilner, Mendez, Hon, Friston and Joyce.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.3389/fpsyt.2013.00176
dc.sourceScopus
dc.subjectDCM
dc.subjectDynamic causal modeling
dc.subjectDysconnectivity
dc.subjectFrontoparietal
dc.subjectMagnetoencephalography
dc.subjectSchizophrenia
dc.typeArticle
dc.contributor.departmentPSYCHOLOGY
dc.description.doi10.3389/fpsyt.2013.00176
dc.description.sourcetitleFrontiers in Psychiatry
dc.description.volume4
dc.description.issueDEC
dc.description.page-
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

36
checked on Oct 18, 2020

Page view(s)

54
checked on Oct 17, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.