ROLE OF MIRNAS IN ENDOTHELIAL DYSFUNCTION

Abstract

DIABETES IS A CHRONIC METABOLIC DISEASE WHICH HAMPERS THE SYSTEMIC GLUCOSE METABOLISM THAT RESULTS IN HYPERGLYCEMIC CONDITION IN THE BLOODSTREAM DUE TO DEFECT IN INSULIN SECRETION, INSULIN ACTION OR BOTH. THE EFFECT OF CHRONIC HYPERGLYCEMIA HAS BEEN LONG TERM ASSOCIATED WITH VASCULAR DYSFUNCTION AND DAMAGE IN VARIOUS TISSUES AND BLOOD VESSELS.BUT UNFORTUNATELY, THESE ENDOTHELIAL CELLS IN THE BLOOD VASCULATURE DAMAGED DUE TO HYPERGLYCEMIA COULD BE IDENTIFIED IN THE LATER STAGE OF THE DISEASE PROGRESSION. THEREFORE, THERE IS A NEED TO IDENTIFY THE ENDOTHELIAL DYSFUNCTION IN ITS EARLY STAGE USING POTENTIAL BIOMARKER. MICRORNAS (MIRNAS) IN THE CIRCULATING BLOOD COULD BE THE POTENTIAL CANDIDATE TO IDENTIFY THE ENDOTHELIAL DYSFUNCTION CAUSED BY HYPERGLYCEMIA. WE HAVE IDENTIFIED 10 MIRNAS (MIR-26A-5P, MIR-26B-5P, MIR-29B-3P, MIR-29C-3P, MIR-125B-1-3P, MIR-130B-3P, MIR-140-5P, MIR-192-5P, MIR-221-3P AND MIR-320A) WERE COMMONLY IDENTIFIED IN HUMAN AND RAT MODEL OF T2DM. OF WHICH, SIX MIRNAS WER