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Title: Memory T Cell Responses Targeting the SARS Coronavirus Persist up to 11 Years Post-Infection
Authors: Ng, Oi Wing 
Chia, Adeline
Tan, Anthony T
Jadi, Ramesh S.
Leong, Hoe Nam
Bertoletti, Antonio 
Tan, Yee Joo 
Keywords: Epitope
T cell
Issue Date: 12-Apr-2016
Publisher: Elsevier Ltd
Citation: Ng, Oi Wing, Chia, Adeline, Tan, Anthony T, Jadi, Ramesh S., Leong, Hoe Nam, Bertoletti, Antonio, Tan, Yee Joo (2016-04-12). Memory T Cell Responses Targeting the SARS Coronavirus Persist up to 11 Years Post-Infection. Vaccine 34 (17) : 2008–2014. ScholarBank@NUS Repository.
Abstract: Severe acute respiratory syndrome (SARS) is a highly contagious infectious disease which first emerged in late 2002, caused by a then novel human coronavirus, SARS coronavirus (SARS-CoV). The virus is believed to have originated from bats and transmitted to human through intermediate animals such as civet cats. The re-emergence of SARS-CoV remains a valid concern due to the continual persistence of zoonotic SARS-CoVs and SARS-like CoVs (SL-CoVs) in bat reservoirs. In this study, the screening for the presence of SARS-specific T cells in a cohort of three SARS-recovered individuals at 9 and 11 years post-infection was carried out, and all memory T cell responses detected target the SARS-CoV structural proteins. Two CD8(+) T cell responses targeting the SARS-CoV membrane (M) and nucleocapsid (N) proteins were characterized by determining their HLA restriction and minimal T cell epitope regions. Furthermore, these responses were found to persist up to 11 years post-infection. An absence of cross-reactivity of these CD8(+) T cell responses against the newly-emerged Middle East respiratory syndrome coronavirus (MERS-CoV) was also demonstrated. The knowledge of the persistence of SARS-specific celullar immunity targeting the viral structural proteins in SARS-recovered individuals is important in the design and development of SARS vaccines, which are currently unavailable.
Source Title: Vaccine
ISSN: 0264410X
DOI: 10.1016/j.vaccine.2016.02.063
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