Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/123723
Title: MECHANISM OF DECANOIC ACID, A DIETARY FATTY ACID, AS A NOVEL THERAPEUTIC AGENT FOR POLYCYSTIC OVARY SYNDROME: CELLULAR, ANIMAL, AND HUMAN STUDIES
Authors: LEE BAO HUI
Keywords: PCOS
Issue Date: 4-Dec-2015
Citation: LEE BAO HUI (2015-12-04). MECHANISM OF DECANOIC ACID, A DIETARY FATTY ACID, AS A NOVEL THERAPEUTIC AGENT FOR POLYCYSTIC OVARY SYNDROME: CELLULAR, ANIMAL, AND HUMAN STUDIES. ScholarBank@NUS Repository.
Abstract: Polycystic ovary syndrome (PCOS), characterized by hyperandrogenism, oligo/anovulation, and polycystic ovaries, is a common cause of infertility in women. Hyperandrogenism is the central feature of PCOS, but current treatment options that target the overproduction of androgens are lacking and there is a clinical need to identify new treatment regimens to improve the management of hyperandrogenism. In this thesis, we investigated the potential clinical utility of decanoic acid (DA), a dietary fatty acid, as a therapeutic agent for PCOS. Using cellular and animal models, we report that DA lowers androgen biosynthesis by inhibiting the enzyme HSD3B2, and reverses the endocrine and metabolic aberrations associated with PCOS. Our clinical study revealed increased HSD3B2 activity in women with PCOS compared to non-PCOS controls, and that increased HSD3B2 activity significantly increases the risk of PCOS. Taken together, our findings uncover the therapeutic potential of DA as a targeted therapy on HSD3B2 hyperactivity in PCOS.
URI: http://scholarbank.nus.edu.sg/handle/10635/123723
Appears in Collections:Ph.D Theses (Open)

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