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Title: Comparison of customized and cohort-based birthweight standards in identification of growth restricted infants in GUSTO cohort study
Authors: Agarwall, Pratibha
Rajadurai, Victor Samuel
Yap, Fabian Kok Peng 
Yeo, George
Chong, Yap Seng 
Kwek, Kenneth Yung Chiang
Saw, Seang Mei 
Gluckman, Peter David
Lee, Yung Seng 
Tan, Kok Hian 
Keywords: Abdominal circumference
customized birthweight centiles
intra uterine growth restriction
small for gestational age
Issue Date: 6-Oct-2015
Publisher: Taylor & Francis
Citation: Agarwall, Pratibha, Rajadurai, Victor Samuel, Yap, Fabian Kok Peng, Yeo, George, Chong, Yap Seng, Kwek, Kenneth Yung Chiang, Saw, Seang Mei, Gluckman, Peter David, Lee, Yung Seng, Tan, Kok Hian (2015-10-06). Comparison of customized and cohort-based birthweight standards in identification of growth restricted infants in GUSTO cohort study. Journal of Maternal-Fetal and Neonatal Medicine : 1-4. ScholarBank@NUS Repository.
Abstract: Background: The aim was to evaluate the ability of customized and cohort birthweight standards in discriminating intrauterine growth retardation (IUGR).Methods: Birthweights (BWs) of GUSTO singleton infants born at gestational age (GA) 35-41 weeks were converted using two standards: (a) GUSTO cohort-based BW centile adjusted for GA and baby gender; (b) customized BW percentile calculator adjusted for maternal height and weight, race, parity, GA and gender. Infants were classified into three groups: (1) < 10th BW centile by customization- customized-SGA, (2) < 10th BW centile by GUSTO- GUSTO-SGA; and (3) > 10th BW centile by both standards - BOTH-non-SGA.Results: Of the 1011 infant-mother dyads, 68 were customized-SGA and 104 were GUSTO-SGA, with concordance of 61% (n = 63) for SGA. While 5 (7%) of customized-SGA were not SGA by GUSTO-charts, 41 (39%) of GUSTO-SGA were not SGA by customized-charts. Customized-SGA had significantly the least growth in abdominal circumference (AC) and highest head circumference (HC): AC growth ratio between second and third trimester; and the lowest mean BW, ponderal index and placental weight than other groups.Conclusion: Customized-SGA standard was a better discriminator of pathologic fetal growth based on AC growth. It improved strength of association with pathology and in our population reduced false positives (41/104 = 39%) in the assessment of SGA. © 2015 Taylor & Francis.
Source Title: Journal of Maternal-Fetal and Neonatal Medicine
ISSN: 14767058
DOI: 10.3109/14767058.2015.1092956
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