Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/122865
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dc.titleFROM HIGH THROUGHPUT INHIBITOR DISCOVERY TO HIGHLY EFFICIENT CELLULAR DELIVERY OF THERAPEUTIC PROTEIN AND DRUG
dc.contributor.authorFU JIAQI
dc.date.accessioned2016-03-31T18:01:19Z
dc.date.available2016-03-31T18:01:19Z
dc.date.issued2015-10-22
dc.identifier.citationFU JIAQI (2015-10-22). FROM HIGH THROUGHPUT INHIBITOR DISCOVERY TO HIGHLY EFFICIENT CELLULAR DELIVERY OF THERAPEUTIC PROTEIN AND DRUG. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/122865
dc.description.abstractDrug discovery is the process through which potential new medicines are identified and brought into market. Advances in technology such as DNA sequencing and combinatorial chemistry have accelerated drug discovery process. However, these technologies always generate library and target proteins at such large scale that is not easy to study. In my thesis, microarray have been used as a high throughput screening platform for the specific ligand discovery of SH2 domains. Further, microarray has been applied to proteomics, the large-scale studies of the performances of bioactive compounds in live cells. Once identified, hits need further optimizations to generate leads. In spite of the effort, most of currently marketed drugs have been suggested to be poorly water-soluble. The difficulty is more pronounced for macromolecules such as proteins and DNAs/siRNAs. In my thesis, we have established a highly efficient delivery system of drugs including both small and large molecules using cell penetrate poly(disulfide)s.
dc.language.isoen
dc.subjectdrug discovery, drug delivery, high throughput, microarray, Cell-Penetrating Poly(disulfide)s
dc.typeThesis
dc.contributor.departmentCHEMISTRY
dc.contributor.supervisorYAO SHAO QIN
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

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