Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/122865
Title: FROM HIGH THROUGHPUT INHIBITOR DISCOVERY TO HIGHLY EFFICIENT CELLULAR DELIVERY OF THERAPEUTIC PROTEIN AND DRUG
Authors: FU JIAQI
Keywords: drug discovery, drug delivery, high throughput, microarray, Cell-Penetrating Poly(disulfide)s
Issue Date: 22-Oct-2015
Citation: FU JIAQI (2015-10-22). FROM HIGH THROUGHPUT INHIBITOR DISCOVERY TO HIGHLY EFFICIENT CELLULAR DELIVERY OF THERAPEUTIC PROTEIN AND DRUG. ScholarBank@NUS Repository.
Abstract: Drug discovery is the process through which potential new medicines are identified and brought into market. Advances in technology such as DNA sequencing and combinatorial chemistry have accelerated drug discovery process. However, these technologies always generate library and target proteins at such large scale that is not easy to study. In my thesis, microarray have been used as a high throughput screening platform for the specific ligand discovery of SH2 domains. Further, microarray has been applied to proteomics, the large-scale studies of the performances of bioactive compounds in live cells. Once identified, hits need further optimizations to generate leads. In spite of the effort, most of currently marketed drugs have been suggested to be poorly water-soluble. The difficulty is more pronounced for macromolecules such as proteins and DNAs/siRNAs. In my thesis, we have established a highly efficient delivery system of drugs including both small and large molecules using cell penetrate poly(disulfide)s.
URI: http://scholarbank.nus.edu.sg/handle/10635/122865
Appears in Collections:Ph.D Theses (Open)

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