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|Title:||CHARACTERIZATION OF LIVER TUMOR INITIATION IN TETON INDUCIBLE ONCOGENE TRANSGENIC ZEBRAFISH||Authors:||HUANG XIAOQIAN||Keywords:||Transgenic zebrafish, HCC Model, Tumor Initiation||Issue Date:||20-Aug-2015||Citation:||HUANG XIAOQIAN (2015-08-20). CHARACTERIZATION OF LIVER TUMOR INITIATION IN TETON INDUCIBLE ONCOGENE TRANSGENIC ZEBRAFISH. ScholarBank@NUS Repository.||Abstract:||Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths globally. Despite the vast amount of research, its initiation process still remains unclear. With our inducible zebrafish HCC model overexpressing two oncogenes (Myc and xmrk), the tumor initiation process can be characterized in details. It is found that there is a rapid transformation of normal hepatic cells into tumor cells within just one week. During the transformation, there is an increase in both cell proliferation and apoptosis, accompanied by disturbed liver metabolism. Interestingly, varying the amount of feeding can also affect HCC progression, implying metabolism's crucial role in HCC development. Moreover, tumor microenvironment can also be studied, and it is found that different oncogene-induced tumors display distinct microenvironment properties. Altogether, these results suggest that zebrafish HCC models can be used to understand HCC initiation and progression, as well as the roles of metabolism and microenvironment in tumorigenic transformation process.||URI:||http://scholarbank.nus.edu.sg/handle/10635/121939|
|Appears in Collections:||Ph.D Theses (Open)|
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