Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/121864
Title: TARGET DECONVOLUTION AND ELUCIDATION OF MECHANISMS OF RESISTANCE OF A NOVEL CLASS OF ANTIMALARIALS
Authors: LIM YI XIU, MICHELLE
Keywords: mechanisms, resistance, antimalarials, target, deconvolution
Issue Date: 14-Aug-2015
Citation: LIM YI XIU, MICHELLE (2015-08-14). TARGET DECONVOLUTION AND ELUCIDATION OF MECHANISMS OF RESISTANCE OF A NOVEL CLASS OF ANTIMALARIALS. ScholarBank@NUS Repository.
Abstract: THE GROWING EMERGENCE OF RESISTANCE TO ANTI-MALARIAL DRUGS HAS BECOME A GLOBAL PROBLEM. AS NEW CLASSES OF DRUGS ARE POISED TO ENTER THE GLOBAL ANTIMALARIAL PIPELINE, UNDERSTANDING THE MECHANISMS OF RESISTANCE (MOR) BECOMES PARAMOUNT FOR DISEASE CONTROL. THIS THESIS REPORTS THE ESTABLISHMENT OF A PLATFORM FOR THE IN VITRO SELECTION OF PLASMODIUM FALCIPARUM DRUG-RESISTANT MUTANTS TO THE NOVEL IMIDAZOLOPIPERAZINE CLASS OF COMPOUNDS. THIS APPROACH HAS SOME UNIQUE ADVANTAGES OVER EXISTING CONVENTIONAL METHODS; SUCH AS (A) MINIMAL GENETIC DRIFT, (B) SIMULTANEOUS SELECTION OF MULTIPLE MUTANTS, (C) DISCOVERY OF NOVEL TARGET(S) OR GENES ASSOCIATED WITH RESISTANCE AND (D) IDENTIFICATION OF RESISTANCE-ASSOCIATED FITNESS COSTS. THE TOOLS DEVELOPED FOR GENOTYPIC AND PHENOTYPIC CHARACTERIZATION OF THE MUTANTS IN THIS THESIS CAN BE APPLIED TO ASSESS THE RISK OF RESISTANCE FOR PRECLINICAL ANTIMALARIAL COMPOUNDS IN DEVELOPMENT. FINALLY, MOLECULAR INFORMATION OBTAINED FROM THIS PROJECT WILL AID IN MONIT
URI: http://scholarbank.nus.edu.sg/handle/10635/121864
Appears in Collections:Ph.D Theses (Open)

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