Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/121863
Title: NOVEL MEMBRANE TARGETING ANTIMICROBIALS FOR DRUG-RESISTANT PATHOGENS
Authors: KOH JUN JIE
Keywords: Xanthone, membrane targeting, antimicrobial, mangosteen, antimicrobial peptide, drug-resistant
Issue Date: 2-Jun-2015
Citation: KOH JUN JIE (2015-06-02). NOVEL MEMBRANE TARGETING ANTIMICROBIALS FOR DRUG-RESISTANT PATHOGENS. ScholarBank@NUS Repository.
Abstract: ANTIBIOTIC RESISTANCE IS A CRITICAL GLOBAL HEALTH CARE CRISIS, WHICH REQUIRES URGENT ACTION TO DEVELOP MORE EFFECTIVE ANTIBIOTICS. THIS STUDY HAS DESIGNED AND TESTED TWO NOVEL MEMBRANE TARGETING ANTIMICROBIALS, WHICH ARE EFFECTIVE AGAINST DRUG-RESISTANT (DR) AND MULTIDRUG-RESISTANT (MDR) RESISTANT PATHOGENS: AMPHIPHILIC XANTHONE DERIVATIVES AND N-LIPIDATED PEPTIDE DIMERS. UTILIZING THE HYDROPHOBIC SCAFFOLD OF XANTHONE, A NUMBER OF POTENT AMPHIPHILIC XANTHONE DERIVATIVES AGAINST GRAM-POSITIVE BACTERIA WERE DEVELOPED. IN GENERAL, SPECIFIC MOLECULAR COMPONENTS ATTACHED TO A CORE MOLECULE WERE REQUIRED TO MIMIC THE MEMBRANE-TARGETING ACTION OF AN ANTIMICROBIAL CATIONIC PEPTIDE. IN ADDITION, IN THIS STUDY, A SERIES OF N-LIPIDATED PEPTIDE-DIMERS (CN-B2088) THAT DISPLAYED POTENT ANTIMICROBIAL ACTIVITIES AGAINST GRAM-NEGATIVE BACTERIA, INCLUDING CARBAPENEM-RESISTANT ENTEROBACTERIACEAE (CRE) WERE IDENTIFIED. THESE COMPOUNDS DISPLAYED POTENT ANTIMICROBIALS WITH DESIRABLE PROPERTIES WHICH INCLUDE
URI: http://scholarbank.nus.edu.sg/handle/10635/121863
Appears in Collections:Ph.D Theses (Open)

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