METAL COMPLEXES WITH ANTI-MICROBIAL PROPERTIES

Abstract

A SERIES OF ELECTRONIC DIFFERENTIATED PORPHYRINS AND METALLOPORPHYRINS WERE DESIGNED AND SYNTHESIZED IN OUR RESEARCH. THEY WERE DESIGNED ACCORDING TO THE INCREASED IN ELECTRON DONATING CAPABILITIES ASSOCIATED WITH DIFFERENT FUNCTIONAL GROUPS (CL, H, METHYL, AND ETHYL) IN THE 4-PHENYL POSITION AS WELL AS SUBSTITUTED BROMINE IN THE 10 AND 20 POSITIONS IN THE PORPHYRIN MACROCYCLE. THE MANGANESE, COBALT AND ZINC WERE SELECTED AS THE CENTRAL METALS OF METALLOPORPHYRINS. ALL THE SYNTHESIZED PORPHYRINS AND METALLOPORPHYRINS WERE TESTED FIRSTLY USING A TECHNIQUE KNOWN AS THE MINIMUM INHIBITION CONCENTRATION TEST IN ORDER TO DETERMINE THEIR ANTI-MICROBIAL PROPERTY AND, SUBSEQUENTLY THEIR CYTOTOXICITY EVALUATED TOWARDS HEALTHY MAMMALIAN CELLS BY DETERMINATION OF HEMOLYSIS OF RABBIT RED BLOOD CELLS AS WELL AS MTT ASSAY OF HUMAN FIBROBLAST CELLS. THE PRELIMINARY RESULTS OBTAINED TO-DATE SUGGESTS POTENTIAL OF THE SYNTHESIZED PORPHYRINS AS A NEW GENERATION OF ANTIBIOTICS FOR TACKLING MULTI-DRUG R