Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/121343
Title: LOCAL CONTROLLABILITY OF BIOLOGICAL NETWORKS
Authors: LUO CHANG
Keywords: Structural controllability, Network controllability, Local controllability, Biological networks, Model networks, linear control systems
Issue Date: 31-Mar-2015
Citation: LUO CHANG (2015-03-31). LOCAL CONTROLLABILITY OF BIOLOGICAL NETWORKS. ScholarBank@NUS Repository.
Abstract: The research on complex networks has gained extensive interest in the last two decades, but studies on network control are relatively recent. With tools from network science and linear system theory, we proposed a new framework for network control, called ?local controllability?, and applied local controllability to biological networks as well as model networks. In this thesis, we will first review some results related to structural controllability and network controllability. Then, we give a mathematical definition for local controllability, and present a cubic-time algorithm to calculating the local controllability . With the framework of local controllability, we will then study biological networks, including mouse inter-region brain networks and human transcription factor regulatory networks; and model networks, including ER random networks and scale-free networks.
URI: http://scholarbank.nus.edu.sg/handle/10635/121343
Appears in Collections:Ph.D Theses (Open)

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