Please use this identifier to cite or link to this item: https://doi.org/10.1111/opo.12212
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dc.titleEye size and shape in newborn children and their relation to axial length and refraction at 3 years
dc.contributor.authorLim, Shen Laurence
dc.contributor.authorChua, Sharon
dc.contributor.authorTan, Pei Ting
dc.contributor.authorCai, Shirong
dc.contributor.authorChong, Yap Seng
dc.contributor.authorKwek, Yung Chiang Kenneth
dc.contributor.authorGluckman, Peter D.
dc.contributor.authorFortier, Marielle V.
dc.contributor.authorNgo, Shufen Cheryl
dc.contributor.authorQiu, Anqi
dc.contributor.authorSaw, Seang-Mei
dc.date.accessioned2015-09-29T05:57:30Z
dc.date.available2015-09-29T05:57:30Z
dc.date.issued2015-07-01
dc.identifier.citationLim, Shen Laurence, Chua, Sharon, Tan, Pei Ting, Cai, Shirong, Chong, Yap Seng, Kwek, Yung Chiang Kenneth, Gluckman, Peter D., Fortier, Marielle V., Ngo, Shufen Cheryl, Qiu, Anqi, Saw, Seang-Mei (2015-07-01). Eye size and shape in newborn children and their relation to axial length and refraction at 3 years. Ophthalmic and Physiological Optics 35 (4) : 414-423. ScholarBank@NUS Repository. https://doi.org/10.1111/opo.12212
dc.identifier.issn02755408
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/121071
dc.description.abstractPurpose: To determine if eye size and shape at birth are associated with eye size and refractive error 3 years later. Methods: A subset of 173 full-term newborn infants from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort underwent magnetic resonance imaging (MRI) to measure the dimensions of the internal eye. Eye shape was assessed by an oblateness index, calculated as 1 - (axial length/width) or 1 - (axial length/height). Cycloplegic autorefraction (Canon Autorefractor RK-F1) and optical biometry (IOLMaster) were performed 3 years later. Results: Both eyes of 173 children were analysed. Eyes with longer axial length at birth had smaller increases in axial length at 3 years (p < 0.001). Eyes with larger baseline volumes and surface areas had smaller increases in axial length at 3 years (p < 0.001 for both). Eyes which were more oblate at birth had greater increases in axial length at 3 years (p < 0.001). Using width to calculate oblateness, prolate eyes had smaller increases in axial length at 3 years compared to oblate eyes (p < 0.001), and, using height, prolate and spherical eyes had smaller increases in axial length at 3 years compared to oblate eyes (p < 0.001 for both). There were no associations between eye size and shape at birth and refraction, corneal curvature or myopia at 3 years. Conclusions: Eyes that are larger and have prolate or spherical shapes at birth exhibit smaller increases in axial length over the first 3 years of life. Eye size and shape at birth influence subsequent eye growth but not refractive error development. © 2015 The College of Optometrists.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1111/opo.12212
dc.publisherWiley
dc.subjectImaging
dc.subjectMagnetic resonance imaging
dc.subjectMyopia
dc.subjectOcular development
dc.typeArticle
dc.contributor.departmentBIOMEDICAL ENGINEERING
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.1111/opo.12212
dc.description.sourcetitleOphthalmic and Physiological Optics
dc.description.volume35
dc.description.issue4
dc.description.page414-423
dc.identifier.isiut000356627100007
dc.published.statePublished
dc.grant.idNMRC/TCR/004-NUS/2008
dc.grant.idNMRC/TCR/012-NUHS/2014
dc.grant.idNUSYIA FY10 P07
dc.grant.fundingagencyNational Medical Research Council (Singapore)
dc.grant.fundingagencyNational University of Singapore
dc.description.seriesGUSTO (Growing up towards Healthy Outcomes)
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