Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2009.07.013
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dc.titleAblation of phosphoinositide-3-kinase class II alpha suppresses hepatoma cell proliferation
dc.contributor.authorNg, S.K.L.
dc.contributor.authorNeo, S.-Y.
dc.contributor.authorYap, Y.-W.
dc.contributor.authorKaruturi, R.K.M.
dc.contributor.authorLoh, E.S.L.
dc.contributor.authorLiau, K.-H.
dc.contributor.authorRen, E.-C.
dc.date.accessioned2015-09-10T04:32:17Z
dc.date.available2015-09-10T04:32:17Z
dc.date.issued2009-09-18
dc.identifier.citationNg, S.K.L., Neo, S.-Y., Yap, Y.-W., Karuturi, R.K.M., Loh, E.S.L., Liau, K.-H., Ren, E.-C. (2009-09-18). Ablation of phosphoinositide-3-kinase class II alpha suppresses hepatoma cell proliferation. Biochemical and Biophysical Research Communications 387 (2) : 310-315. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2009.07.013
dc.identifier.issn0006291X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/120842
dc.description.abstractCancer such as hepatocellular carcinoma (HCC) is characterized by complex perturbations in multiple signaling pathways, including the phosphoinositide-3-kinase (PI3K/AKT) pathways. Herein we investigated the role of PI3K catalytic isoforms, particularly class II isoforms in HCC proliferation. Among the siRNAs tested against the eight known catalytic PI3K isoforms, specific ablation of class II PI3K alpha (PIK3C2α) was the most effective in impairing cell growth and this was accompanied by concomitant decrease in PIK3C2α mRNA and protein levels. Colony formation ability of cells deficient for PIK3C2α was markedly reduced and growth arrest was associated with increased caspase 3 levels. A small but significant difference in gene dosage and expression levels was detected between tumor and non-tumor tissues in a cohort of 19 HCC patients. Taken together, these data suggest for the first time that in addition to class I PI3Ks in cancer, class II PIK3C2α can modulate HCC cell growth. © 2009 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bbrc.2009.07.013
dc.sourceScopus
dc.subjectApoptosis
dc.subjectCell growth
dc.subjectHCC
dc.subjectLiver
dc.subjectPhosphoinositide-3-kinase
dc.subjectPI3K
dc.subjectPIK3C2α
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY
dc.description.doi10.1016/j.bbrc.2009.07.013
dc.description.sourcetitleBiochemical and Biophysical Research Communications
dc.description.volume387
dc.description.issue2
dc.description.page310-315
dc.description.codenBBRCA
dc.identifier.isiut000268978200017
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