Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/120787
DC FieldValue
dc.titleUltrastructural changes in the hypothalamic paraventricular nucleus of the streptozotocin-induced diabetic rat
dc.contributor.authorDHEEN,SHAIKALI THAMEEM
dc.contributor.authorTay, S.S.W.
dc.contributor.authorWong, W.C.
dc.date.accessioned2015-09-09T07:03:51Z
dc.date.available2015-09-09T07:03:51Z
dc.date.issued1994
dc.identifier.citationDHEEN,SHAIKALI THAMEEM, Tay, S.S.W., Wong, W.C. (1994). Ultrastructural changes in the hypothalamic paraventricular nucleus of the streptozotocin-induced diabetic rat. Acta Anatomica 149 (4) : 291-299. ScholarBank@NUS Repository.
dc.identifier.issn00015180
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/120787
dc.description.abstractThis study describes the ultrastructural and morphometric changes in the hypothalamic paraventricular nucleus (PVN)) of the streptozotocin-induced diabetic rat. During the acute phase (3 days after induction of diabetes), dendrites were swollen and appeared to have a watery cytoplasm. The affected dendrites were postsynaptic to seemingly normal axon terminals. During the intermediate phase (1-9 months after induction of diabetes), the neuronal somata contained numerous vacuoles of various sizes which were probably formed from dilated rough endoplasmic reticulum. Several unidentifiable vacuolated profiles were also seen in the neuropil. During the late phase (12 months after induction of diabetes) electron-dense dendrites and axon terminals were readily encountered in the neuropil. Most of the electron-dense dendrites were postsynaptic to normal as well as electron-dense axon terminals. Some of the electron-dense axon terminals formed axosomatic synapses with seemingly normal somata. Perivascular glial cells in the neuropil were in the process of phagocytosis. At 1-12 months of diabetes, the sizes of the somata and nuclei of PVN neurons were significantly increased in comparison with age-matched control rats.
dc.sourceScopus
dc.subjectDiabetes mellitus
dc.subjectHypothalamus
dc.subjectParaventricular nucleus
dc.subjectRat
dc.subjectStreptozotocin
dc.typeArticle
dc.contributor.departmentANATOMY
dc.description.sourcetitleActa Anatomica
dc.description.volume149
dc.description.issue4
dc.description.page291-299
dc.description.codenACATA
dc.identifier.isiutNOT_IN_WOS
dc.published.stateUnpublished
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