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|Title:||NADPH-diaphorase activity in the nodose ganglion of normal and vagotomized guinea-pigs||Authors:||Wang, X.-Y.
|Issue Date:||1996||Citation:||Wang, X.-Y., Wong, W.-C., Ling, E.-A. (1996). NADPH-diaphorase activity in the nodose ganglion of normal and vagotomized guinea-pigs. Cell and Tissue Research 285 (1) : 141-147. ScholarBank@NUS Repository. https://doi.org/10.1007/s004410050629||Abstract:||The activity and distribution of reduced nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-diaphorase) in the nodose ganglion of normal and vagotomized guinea-pigs were examined by light and electron microscopy. Light microscopy confirmed a remarkable increase in the number of NADPH-diaphorase-reactive neurons in the nodose ganglion following unilateral cervical vagotomy. The increase was present at 5 days but became more prominent at 10 days and was sustained until at least 30 days after vagotomy when compared with the non-lesioned side. The NADPH-diaphorase reaction product was associated with the membrane of the rough endoplasmic reticulum, Golgi apparatus, mitochondria and nucleus of the nodose neurons. In animals killed 5 days post-operation, there was no noticeable degeneration in the nodose neurons. However, at 10 days, the mitochondria in some neurons appeared swollen and vacuolated with disrupted cristae. These changes were accentuated in some nodose neurons 20 and 30 days after vagotomy but there was no evidence of cell death. All the degenerating neurons exhibited NADPH-diaphorase activity. The increase in NADPH-diaphorase activity in the neuronal somata after vagotomy suggests that the enzyme is involved in either the retrograde degeneration or the recovery of the lesioned neurons.||Source Title:||Cell and Tissue Research||URI:||http://scholarbank.nus.edu.sg/handle/10635/120770||ISSN:||0302766X||DOI:||10.1007/s004410050629|
|Appears in Collections:||Staff Publications|
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