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Title: Immunohistochemical expression of heparan sulfate correlates with stromal cell proliferation in breast phyllodes tumors
Authors: Koo, C.-Y.
Bay, B.-H. 
Lui, P.C.-W.
Tse, G.M.-K.
Tan, P.-H. 
Yip, G.W.-C. 
Keywords: Heparan sulfate
Phyllodes tumor grade
Tissue microarray
Issue Date: 21-Oct-2006
Citation: Koo, C.-Y., Bay, B.-H., Lui, P.C.-W., Tse, G.M.-K., Tan, P.-H., Yip, G.W.-C. (2006-10-21). Immunohistochemical expression of heparan sulfate correlates with stromal cell proliferation in breast phyllodes tumors. Modern Pathology 19 (10) : 1344-1350. ScholarBank@NUS Repository.
Abstract: Phyllodes tumors are fibroepithelial neoplasms typified by stromal proliferation. We have previously shown the role of pathologic parameters and the prognostic significance of p53 and CD117 protein expression in these tumors. In this study, we evaluated the expression of heparan sulfate, which has been implicated in many biological processes such as cell adhesion, embryogenesis, and tumorigenesis (including malignant transformation of mammary cells) in 232 breast phyllodes tumors. We used a monoclonal antibody, 10E4, to examine the localization of heparan sulfate in phyllodes tumors by immunohistochemistry. The immunoreactivity of both epithelial and stromal components was examined and analyzed with pathological parameters and other immunohistochemical markers, including p53, MIB1, bcl2, and CD117. Stromal 10E4 expression was significantly associated with tumor grade, stromal p53, and MIB1 expression in proliferating cells, suggesting that heparan sulfate may participate in malignant tumor growth. © 2006 USCAP, Inc. All rights reserved.
Source Title: Modern Pathology
ISSN: 08933952
DOI: 10.1038/modpathol.3800657
Appears in Collections:Staff Publications

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