Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/120570
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dc.titleRNA EDITING INDEPENDENT FUNCTIONS OF ADENOSINE DEAMINASES ACTING ON DOUBLE-STRANDED RNA IN HEPATOCELLULAR CARCINOMA
dc.contributor.authorQI LIHUA
dc.date.accessioned2015-08-31T18:00:42Z
dc.date.available2015-08-31T18:00:42Z
dc.date.issued2015-01-14
dc.identifier.citationQI LIHUA (2015-01-14). RNA EDITING INDEPENDENT FUNCTIONS OF ADENOSINE DEAMINASES ACTING ON DOUBLE-STRANDED RNA IN HEPATOCELLULAR CARCINOMA. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/120570
dc.description.abstractADENOSINE DEAMINASES ACTING ON DOUBLE-STRANDED RNA (DSRNA) (ADARS) IS A FAMILY OF ENZYMES CATALYSING ADENOSINE TO INOSINE CONVERSION (A-TO-I EDITING). IF HAPPENED IN CODING REGIONS, A-TO-I EDITING CAN CAUSE PROTEIN RECODING. RECODING EDITING HAS BEEN REPORTED TO CONTRIBUTE TO HEPATOCELLULAR CARCINOMA (HCC) DEVELOPMENT. HOWEVER A-TO-I EDITING IS MOSTLY ENRICHED IN 3? UNTRANSLATED REGIONS (3?UTRS) AND THE ASSOCIATED FUNCTIONS REMAIN LARGELY UNCLEAR. HERE, WE INVESTIGATED THE REGULATIONS OF ADARS ON TARGET GENES WITH EXTENSIVE 3?UTR EDITING. USING RNA-SEQ AND LUCIFERASE REPORTER ASSAYS, WE IDENTIFIED A NOVEL TUMOR SUPPRESSOR GENE METTL7A (METHYLTRANSFERASE LIKE 7A) AS A BONA FIDE 3?UTR EDITING TARGET OF ADARS. HCC PATIENTS WITH LOWER METTL7A EXPRESSION WERE PREDICTED TO HAVE POORER SURVIVAL PROBABILITY. MORE IMPORTANTLY, WE REVEALED THAT ADARS SUPPRESSED METTL7A EXPRESSION INDEPENDENT OF THEIR RNA EDITING ACTIVITIES BY INTERACTING WITH DICER, WHICH PROMOTES THE EXPRESSION OF MIR-27A THAT
dc.language.isoen
dc.subjectRNA, Editing, Independent, Functions, ADARs, HCC
dc.typeThesis
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.supervisorDANIEL G. TENEN
dc.contributor.supervisorCHEN LEILEI
dc.description.degreePh.D
dc.description.degreeconferredPHD IN CANCER BIOLOGY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

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