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Title: | A SYSTEMATIC INTEGRATIVE ANALYSIS AND FUNCTIONAL GENOMICS OF MELANOMA MAINTENANCE | Authors: | FARANAK GHAZI SHERBAF | Keywords: | melanoma, Next generation sequencing, functional genomics, tumor's functional maintenance, systems biology, synergistic therapy | Issue Date: | 21-Jan-2015 | Citation: | FARANAK GHAZI SHERBAF (2015-01-21). A SYSTEMATIC INTEGRATIVE ANALYSIS AND FUNCTIONAL GENOMICS OF MELANOMA MAINTENANCE. ScholarBank@NUS Repository. | Abstract: | IN VIEW OF THE HIGHLY HETEROGENEOUS MUTATIONAL SIGNATURE OF MELANOMA, IT IS IMPORTANT TO DEVELOP SUCCESSFUL THERAPIES TO IDENTIFY COOPERATING ONCOGENES AND RECONSTITUTE THE GENOMIC ARCHITECTURE THAT DRIVES THEIR SYNERGISTIC EFFECTS. I INVESTIGATED THE SYSTEMS BIOLOGY OF A TUMOR?S FUNCTIONAL MAINTENANCE IN MELANOMA AS DEFINED BY HARDWIRED SOMATIC MUTATIONS. INTEGRATIVE ANALYSIS AND FUNCTIONAL VALIDATION IN ONE MELANOMA PATIENT WITH A COMPLEX SET OF TUMORS AND CELL LINES CONFIRMED THE BIOLOGICAL SIGNIFICANCE OF THESE SOMATIC EVENTS, AND SUGGESTED THE PRESENCE OF A FUNCTIONAL MODULE. A MAINTENANCE FUNCTIONAL MODULE IS DEFINED AS A CORE SET OF SOMATIC EVENTS PERSISTING THROUGHOUT THE TUMOR EVOLUTION OF ANY MELANOMA PATIENT, PERFORMING IN A COOPERATIVE MANNER WITH SIGNIFICANT EFFECT ON TUMOR PROLIFERATION. FINALLY, I DISCOVERED A UNIVERSAL FUNCTIONAL MODULE IN MELANOMA. THE SIGNIFICANT ENRICHMENT OF THIS MODULE ON SEVERAL CHROMOSOMAL SEGMENTS SUGGESTS THE IMPORTANCE OF THESE SEGMENTS HARBOR | URI: | http://scholarbank.nus.edu.sg/handle/10635/120528 |
Appears in Collections: | Ph.D Theses (Open) |
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Faranak Ghazi Sherbaf (GhaziSherbafF.pdf).pdf | 23.43 MB | Adobe PDF | OPEN | None | View/Download |
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