Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/119592
Title: INSIGHTS INTO THE ROLE OF MICRORNAS IN HEPATOCELLULAR CARCINOMA
Authors: THURNHERR THOMAS M
Keywords: genomics, microRNA, hepatocellular carcinoma, microarray, computational biology, high-throughput
Issue Date: 22-Dec-2014
Citation: THURNHERR THOMAS M (2014-12-22). INSIGHTS INTO THE ROLE OF MICRORNAS IN HEPATOCELLULAR CARCINOMA. ScholarBank@NUS Repository.
Abstract: MICRORNAS (MIRNAS) HAVE BEEN IMPLICATED IN HUMAN CANCERS THROUGH PROFILING AND FUNCTIONAL STUDIES. TRADITIONALLY, THESE STUDIES FOCUS ON A SINGLE MIRNA OR FAMILY OF MIRNAS AND A SMALL NUMBER OF TARGETS. WE EMPLOYED A SYSTEMATIC APPROACH TO STUDY THE ROLE OF MIRNAS AND THEIR TARGETS IN HEPATOCELLULAR CARCINOMA (HCC) BY INTEGRATING MIRNA AND MRNA EXPRESSION PROFILES OF 100 TUMORS AND ADJACENT NON-TUMOROUS TISSUES OF HCC PATIENTS, COMBINED WITH TARGET PREDICTIONS. WE IDENTIFIED SIX DIFFERENTIALLY EXPRESSED AND POTENTIALLY RELEVANT MIRNAS. MIR-21, MIR-93, AND MIR-221 ARE UP-REGULATED IN HCC AND THEIR TARGETS ARE INVOLVED IN PROCESSES RELATED TO METABOLISM AND IMMUNE-SYSTEM RESPONSE. MIR-26A, MIR-122, AND MIR-130A ARE DOWN-REGULATED IN HCC AND THEIR TARGETS ARE ASSOCIATED WITH CELL-CYCLE PROCESSES IN GENERAL AND DNA REPLICATION AND REPAIR SPECIFICALLY. OUR FINDINGS FURTHER SUGGEST THAT THESE MIRNAS COLLABORATIVELY MODULATE THESE CRITICAL CELLULAR PATHWAYS THROUGH DISTINCT SETS OF TARGETS. T
URI: http://scholarbank.nus.edu.sg/handle/10635/119592
Appears in Collections:Ph.D Theses (Open)

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