Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/119285
Title: Part I: Synthesis and Biological Evaluation of Phosphoglycolipid PGL1 Analogues; Part II: Synthesis and Biological Evaluation of Andrographolide Analogues
Authors: HADHI WIJAYA
Keywords: Hadhi Thesis
Issue Date: 22-Jul-2014
Citation: HADHI WIJAYA (2014-07-22). Part I: Synthesis and Biological Evaluation of Phosphoglycolipid PGL1 Analogues; Part II: Synthesis and Biological Evaluation of Andrographolide Analogues. ScholarBank@NUS Repository.
Abstract: In the first part of this thesis, the synthesis and biological evaluation of phosphoglycolipid PGL1 analogues are described. PGL1 is a phosphoglycolipid isolated from the thermophilic bacteria Thermus and Meiothermus species. It was found to possess immunomodulatory functions. In order to study the biological functions of PGL1 as well as to identify its cellular receptor, a feasible synthetic route towards this phosphoglycolipid was developed. A library of PGL1 analogues having a variety of fatty acid chains (in terms of length and branching pattern) was obtained and subjected to biological evaluation. The second part of the thesis deals with the synthesis and biological evaluation of andrographolide analogues. Andrographolide is a natural product, which has been widely used as traditional medicine in China, India and other Asian countries. This natural product has been reported to exhibit a wide range of biological activities such as anticancer, antibacterial and anti-inflammatory, etc. To identity the cellular targets of this natural product, a series of activity-based probes were developed. In addition, a series of andrographolide analogues were synthesized to evaluate their inhibitory activity against NF-kB.
URI: http://scholarbank.nus.edu.sg/handle/10635/119285
Appears in Collections:Ph.D Theses (Open)

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