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|Title:||Exploring Mesenchymal Stem Cell-Derived Exosome and Tocotrienol (T3) as Therapeutic Agents in Drug-Induced Liver Injury (DILI)||Authors:||TAN CHEAU YIH||Keywords:||Mesenchymal Stem cell, exosomes, tocotrienol, drug-induced liver injury, acetaminophen, Carbon tetrachloride||Issue Date:||4-Aug-2014||Citation:||TAN CHEAU YIH (2014-08-04). Exploring Mesenchymal Stem Cell-Derived Exosome and Tocotrienol (T3) as Therapeutic Agents in Drug-Induced Liver Injury (DILI). ScholarBank@NUS Repository.||Abstract:||Drug-induced acute liver injury (DILI) is a major clinical problem arising from both diseases and therapeutic misadventures. Management of DILI is often limited to cessation of drug use and supportive therapy, as there are no therapeutically proven natural hepatoprotective agents. Therefore, the overarching aim of this thesis was to determine if MSC-CM derived exosomes and isoforms of T3 are hepatoregenerative and/or hepatoprotective in overcoming DILI. In summary, the results suggest that MSC-derived exosomes can elicit hepatoprotective and hepatoregenerative effects against toxicants-induced injury mainly through activation of proliferative and regenerative responses while a-T3 prevented the hepatocytes injuries caused by oxidative stress during DILI through its potent antioxidant properties. These two agents participate distinctively in different aspects of hepatoprotection and hepatoregeneration, alluding to a potential enhancement of effect when applied collaboratively.||URI:||http://scholarbank.nus.edu.sg/handle/10635/119261|
|Appears in Collections:||Ph.D Theses (Open)|
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