Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/119213
Title: DESIGN OF POLYMERIC CARRIERS BASED ON GREEN TEA CATECHIN FOR CANCER THERAPY
Authors: LIANG KUN
Keywords: Cancer therapy, Nanomedicine, Drug delivery, EGCG
Issue Date: 4-Aug-2014
Citation: LIANG KUN (2014-08-04). DESIGN OF POLYMERIC CARRIERS BASED ON GREEN TEA CATECHIN FOR CANCER THERAPY. ScholarBank@NUS Repository.
Abstract: MANY DRUG DELIVERY SYSTEMS (DDS) HAVE BEEN DEVELOPED IN RECENT YEARS TO ACHIEVE THE INTENDED SPECIFIC DELIVERY OF ANTICANCER DRUGS TO SITES WHERE TUMORS ARE LOCATED BUT AN IDEAL DDS REMAINS ELUSIVE. FAILURES OF DDS SUCH AS SIDE EFFECTS AND LOW ANTITUMOR ACTIVITY CAN BE ATTRIBUTED IN PART TO INABILITY TO ATTAIN OPTIMAL INTERACTION BETWEEN DRUG AND THE CARRIER. GREEN TEA CATECHIN, EGCG ((-)-EPIGALLOCATECHIN-3-GALLATE), WHICH HAS BEEN WIDELY REPORTED TO POSSESS ANTI-CARCINOGENIC EFFECTS, HAS A MULTIPLE-RINGED STRUCTURE THAT ENABLE IT TO INTERACT FAVORABLY WITH ANTICANCER DRUGS. HENCE WE ARE INTERESTED TO DESIGN NOVEL POLYMERIC CARRIERS BASED ON EGCG TO DELIVER A VARIETY OF ANTICANCER THERAPEUTICS. THESE CARRIERS WERE FOUND TO HAVE HIGH LOADING CAPACITY, STABILITY AND SIGNIFICANT ANTITUMOR EFFICACY. IN ADDITION, EGCG-BASED POLYMERIC CARRIERS WERE ALSO ABLE TO ACHIEVE SELECTIVE INTRACELLULAR DELIVERY OF PROTEIN AND DNA, PROVIDING A STRATEGY TO TARGET CANCER CELLS. IN SUMMARY, EGCG-BASED CAR
URI: http://scholarbank.nus.edu.sg/handle/10635/119213
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