ROLE OF TRANSCRIPTION FACTORS, RUNXITI AND PPAR¿ AND A HERBAL COMPOUND COSTUNOLIDE IN MODULATING THE ACTIVATION OF RODENT MICROGLIA

Abstract

MICROGLIA, THE RESIDENT IMMUNE CELLS OF THE BRAIN, UNDERGO RAPID PROLIFERATION AND PRODUCE TOXIC MOLECULES WHEN ACTIVATED IN NEUROPATHOLOGIES. THIS STUDY IS MAINLY FOCUSED ON IDENTIFYING THE ROLE OF TRNSCRIPTION FACTORS SUCH AS RUNT-RELATED TRANSCRIPTION FACTOR 1; TRANSLOCATED TO 1 (RUNX1T1) AND PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ¿ (PPAR¿) IN MODULATING THE ACTIVATION OF MICROGLIA, AND ON ELUCIDATING THE MECHANISM OF ACTION OF COSTUNOLIDE, A HERBAL COMPOUND ON THE INFLAMMATORY REACTIONS OF ACTIVATED MICROGLIA AFTER TRAUMATIC BRAIN INJURY. IT HAS BEEN SHOWN THAT RUNX1T1 CONTROLS THE PROLIFERATION AND NEUROTOXIC EFFECT OF MICROGLIA BY EPIGENETICALLY REGULATING CDK4 AND L-AMINOACID TRANSPORTER-2 (LAT2) VIA ITS INTERACTION WITH HISTONE DEACETYLASES (HDACS). FURTHER, THIS STUDY CONFIRMED THAT COSTUNOLIDE DELIVERS ITS INHIBITORY EFFECTS ON MICROGLIA BY BINDING AND ACTIVATING PPAR¿, AN INHIBITOR OF NFKB SIGNALING PATHWAY.