BIOACCUMULATION, TISSUE DISTRIBUTION AND MATERNAL TRANSFER OF IONOGENIC ORGANIC CONTAMINANTS IN ZEBRAFISH (DANIO RERIO)

Abstract

THE OCCURRENCE OF PHARMACEUTICALS AND PERSONAL CARE PRODUCTS (PPCPS) AND PERFLUORINATED COMPOUNDS (PFCS) IN THE ENVIRONMENT HAS RAISED PUBLIC HEALTH CONCERNS IN RECENT YEARS. THE BIOACCUMULATION BEHAVIOR OF THESE IONOGENIC ORGANIC CONTAMINANTS (IOCS) IN AQUATIC ORGANISMS IS NOT WELL UNDERSTOOD. THIS THESIS INVOLVES A SERIES OF LABORATORY INVESTIGATIONS TO ASSESS THE BIOACCUMULATION BEHAVIOR OF SEVERAL PPCPS AND PFCS IN ZEBRAFISH (DANIO RERIO), A COMMON AQUATIC VERTEBRATE MODEL USED FOR AQUATIC AND HUMAN TOXICOLOGY STUDIES. PPCPS INVESTIGATED INCLUDED CARBAMAZEPINE, DICLOFENAC, IBUPROFEN, NAPROXEN, TRICLOSAN, DIPHENHYDRAMINE, GEMFIBROZIL, SERTRALINE, RISPERIDONE AND SIMVASTATIN, FLUOXETINE AND BISPHENOL A (BPA). PFCS INCLUDED PERFLUOROALKYL CARBOXYLIC ACIDS (PFCAS), PERFLUOROALKYL SULFONIC ACIDS AND MONO- AND DI-PERFLUOROALKYL PHOSPHONIC ACIDS (PFPAS). CONTINUOUS FLOW-THROUGH EXPOSURE EXPERIMENTS WERE DESIGNED AND IMPLEMENTED TO ASSESS UPTAKE AND ELIMINATION KINETICS, HALF-LIVES, TISSUE