Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/118736
DC Field | Value | |
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dc.title | A NOVEL ROLE OF THE MECHANO-SENSING PROTEIN P130CAS IN SUPPORTING BONE HOMEOSTASIS | |
dc.contributor.author | ZHIHAI ZHAO | |
dc.date.accessioned | 2015-02-12T18:00:30Z | |
dc.date.available | 2015-02-12T18:00:30Z | |
dc.date.issued | 2014-08-21 | |
dc.identifier.citation | ZHIHAI ZHAO (2014-08-21). A NOVEL ROLE OF THE MECHANO-SENSING PROTEIN P130CAS IN SUPPORTING BONE HOMEOSTASIS. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/118736 | |
dc.description.abstract | A VARIETY OF BIOLOGICAL EVENTS, INCLUDING INFLAMMATORY RESPONSES, ARE SUBJECT TO MECHANICAL INFLUENCE. HOWEVER, IT REMAINS LARGELY ELUSIVE HOW INFLAMMATION-RELATED SIGNALING IS MECHANICALLY MODULATED. HERE WE SHOW THAT P130CAS (CRK-ASSOCIATED SUBSTRATE, HEREAFTER REFERRED TO AS CAS), WHICH HAS PREVIOUSLY BEEN REPORTED TO ACT AS A CELLULAR MECHANO-SENSOR, PARTICIPATES IN INFLAMMATORY SIGNALING. UPON TREATMENT WITH THE INFLAMMATORY CYTOKINE TNF-A, CAS TRANSLOCATES INTO THE NUCLEUS AND INTERFERES WITH THE PHYSICAL ASSOCIATION BETWEEN THE ACETYLTRANSFERASE P300 AND NF-KB. WE FURTHER TEST IF THE MECHANOSENSING MOLECULE CAS PLAYS A ROLE IN THE RESPONSE OF OSTEOCYTES TO SHEAR FLOW. OSTEOCYTE-SPECIFIC CAS KNOCKOUT MICE EXHIBIT AN OSTEOPENIA ASSOCIATED WITH AN INCREASED OSTEOCLASTIC BONE RESORPTION BASED ON AN ENHANCED RANKL EXPRESSION DEPENDING ON NF-KB. THE RESULTS SHOW THAT THE CAS-NF-KB AXIS SUPPORTS THE NORMAL BONE METABOLISM, PROVIDING NOVEL INSIGHTS INTO THERAPEUTIC STRATEGIES FOR ATRO | |
dc.language.iso | en | |
dc.subject | p130Cas, bone metabolism, mechano-sensing, NF-κB, osteocytes, RANKL | |
dc.type | Thesis | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.contributor.supervisor | SAWADA, YASUHIRO | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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ZHAOZH.pdf | 3.44 MB | Adobe PDF | OPEN | None | View/Download |
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