Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/118735
Title: EFFECTS OF FLUID SHEAR STRESS ON MESENCHYMAL STEM CELL CONTRACTILITY AND FATE
Authors: SURABHI SONAM
Keywords: Fluid Shear Stress, Human Mesenchymal Stem Cell, Differentiation, Cell Contractility, Microfluidics, Micro-topographies
Issue Date: 1-Aug-2014
Citation: SURABHI SONAM (2014-08-01). EFFECTS OF FLUID SHEAR STRESS ON MESENCHYMAL STEM CELL CONTRACTILITY AND FATE. ScholarBank@NUS Repository.
Abstract: Fluid shear stress (FSS) impinges on intracellular contractility and also directs stem cell fate.However, the relationship between contractility and FSS mediated differentiation remains unclear. Here, we hypothesize that applied FSS can induce changes in the contractility and shape of a stem cell, and hence regulate its lineage determination. To understand the modular mechanism, we, first, identified FSS induced morphological and molecular changes occurring in hMSCs, leading to altered contractility and lineage determination. Increased cellular contractility allowed FSS mediated osteogenesis in hMSCs. Several drug tests and biophysical techniques were employed to influence the contractility of hMSCs while facing FSS.
URI: http://scholarbank.nus.edu.sg/handle/10635/118735
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
SONAM Surabhi-Full Thesis.pdf7.92 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

143
checked on Oct 10, 2020

Download(s)

97
checked on Oct 10, 2020

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.