Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/118632
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dc.titleSTEM CELL- AND DENDRITIC CELL-BASED CANCER IMMUNOTHERAPY TARGETING CANCER STEM CELLS
dc.contributor.authorCHEN CAN
dc.date.accessioned2015-02-03T18:00:19Z
dc.date.available2015-02-03T18:00:19Z
dc.date.issued2014-08-15
dc.identifier.citationCHEN CAN (2014-08-15). STEM CELL- AND DENDRITIC CELL-BASED CANCER IMMUNOTHERAPY TARGETING CANCER STEM CELLS. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/118632
dc.description.abstractIN THIS PHD PROJECT, WE EXPLORED THE POTENTIAL OF STEM CELL- AND DENDRITIC CELL-BASED CANCER IMMUNOTHERAPY TO TARGET CANCER METASTASIS AND CANCER STEM CELL (CSC). IN STEM CELL PART, WE GENERATED NSCS FROM HIPSCS. WE FOUND THAT NEURONAL NITRIC OXIDE SYNTHASE (NNOS) WAS A RELEVANT REGULATOR IN CONTROLLING HIPSC-NSCS TUMOR TROPISM, AND NNOS INHIBITION COULD SENSITIZE POORLY MIGRATORY NSCS, HENCE IMPROVING THEIR TUMOR TROPISM. FURTHERMORE, OUR RESULTS DEMONSTRATE THE TREATMENT UTILIZING HIPSC-NSCS ENGINEERED WITH CD40 LIGAND (CD40L) COULD SIGNIFICANTLY IMPEDE THE TUMOR GROWTH. IN DENDRITIC CELL PART, WE CONFER CERTAIN CANCER STEM-LIKE PROPERTIES TO HUMAN GLIOMA CELLS BY REPROGRAMMING. HUMAN DENDRITIC CELLS LOADED WITH LYSATES OF CANCER STEM-LIKE CELLS WERE CAPABLE OF ELICITING CSC ANTIGEN SPECIFIC T-CELL RESPONSE IN VITRO. THEREFORE, WE ENVISION THAT REPROGRAMMED CANCER STEM-LIKE CELLS CAN BE USED AS A READILY ACCESSIBLE SOURCE TO PROVIDE CSC-RELATED ANTIGENS FOR DENDRITIC CELL IMMUNOTHE
dc.language.isoen
dc.subjectneural stem cell, dendritic cell, cancer immunotherapy
dc.typeThesis
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.supervisorWANG SHU
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
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