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https://scholarbank.nus.edu.sg/handle/10635/118472
DC Field | Value | |
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dc.title | FUNCTIONAL SIGNIFICANCE AND EXPRESSION ANALYSIS OF N-ACETYL GALACTOSAMINYL TRANSFERASE-1 IN BREAST CANCER | |
dc.contributor.author | SIM WEY CHENG | |
dc.date.accessioned | 2015-01-16T18:00:15Z | |
dc.date.available | 2015-01-16T18:00:15Z | |
dc.date.issued | 2013-08-23 | |
dc.identifier.citation | SIM WEY CHENG (2013-08-23). FUNCTIONAL SIGNIFICANCE AND EXPRESSION ANALYSIS OF N-ACETYL GALACTOSAMINYL TRANSFERASE-1 IN BREAST CANCER. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/118472 | |
dc.description.abstract | BREAST CANCER IS THE TOP LEADING CAUSE OF CANCER AND MORTALITY IN WOMEN WORLDWIDE AND IN SINGAPORE. IN CURRENT STUDY, CSGALNACT-1 ENZYME, WHICH INITIATES THE BIOSYNTHESIS OF CHONDROITIN SULFATE, WAS FOUND UP-REGULATED IN NORMAL BREAST CELL LINE, MCF-12A; BUT DOWN-REGULATED IN BREAST CANCER CELL LINES, I.E. MCF7, ZR75-1 AND MDA-MB-231. HENCE, THE FUNCTIONAL ROLE OF CSGALNACT-1 WAS EXAMINED BY SILENCING AND OVER-EXPRESSING THIS GENE IN THE RESPECTIVE CELL LINES. RESULTS SHOWED THAT CSGALNACT-1 WAS INVOLVED IN REGULATING CELL MIGRATION, INVASION, SURVIVAL AND ADHESION. BESIDES, MICROARRAY ANALYSIS SHOWED THAT SILENCING CSGALNACT-1 RESULTED IN CHEMOKINE CXCL14 UP-REGULATION. IT WAS HYPOTHESIZED THAT CXCL14 MEDIATED THE PHENOTYPIC CHANGES IN MCF-12A DOWNSTREAM OF CSGALNACT-1 AND THIS WAS PROVEN THROUGH DOUBLE KNOCKDOWN EXPERIMENTS. IMMUNOHISTOCHEMISTRY WAS PERFORMED TO DETERMINE THE LOCALIZATION OF CSGALNACT-1 IN BREAST INVASIVE DUCTAL CARCINOMA CLINICAL SAMPLES. THE EXPRESSION OF CSGALNACT | |
dc.language.iso | en | |
dc.subject | N-acetylgalactosaminyltransferase-1, CSGalNAcT-1, breast cancer, breast invasive ductal carcinoma, CXCL14, chondroitin sulfate | |
dc.type | Thesis | |
dc.contributor.department | ANATOMY | |
dc.contributor.supervisor | YIP WAI CHEONG, GEORGE | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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File | Description | Size | Format | Access Settings | Version | |
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SimWC.pdf | 4.94 MB | Adobe PDF | OPEN | None | View/Download |
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